ArticleCancer management and research2025
A Multicenter Retrospective Analysis on Lymph Node Metastasis in Clinically Node-Negative (cN0) Patients with Small-Sized Breast Cancer.
Article in Cancer management and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Sentinel lymph node biopsy (SLNB) is the standard for early breast cancer, but its necessity in small tumors with clinically node-negative (cN0) status remains debated. This study evaluated the incidence of lymph node metastasis in cN0 patients to explore the feasibility of omitting axillary surgery. Methods: A cohort of 579 women with unilateral small breast cancer and cN0 were enrolled from three hospitals in Jiangsu Province (March 2023-June 2024). Clinical nodal status was determined by ultrasonography, while pathology and immunohistochemistry assessed tumor size, node status, and molecular subtypes. Chi-square tests and logistic regression were used for analysis. Results: Lymph node metastasis was detected in 79 patients (13.64%). Tumors ≤20 mm and Ki-67 ≤14% showed significantly lower metastasis rates (P < 0.0001 and P = 0.013, respectively). Even in cN0 patients with both favorable factors, 6.15% still had nodal involvement. Logistic regression identified tumor size (T2) as an independent predictor of metastasis. Conclusion: Small breast cancer with cN0 and low Ki-67 expression is associated with reduced but non-negligible nodal metastasis. These findings support caution in omitting axillary surgery and highlight the need for individualized risk stratification rather than universal omission.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.