ArticleCardiovascular therapeutics2025
Antiatherogenic and Cardioprotective Effects of a Xanthine Derivative KMUP-1 in ApoE Knockout Mice.
Article in Cardiovascular therapeutics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
It is essential to manage cardiovascular disease related to atherosclerosis through understanding its disease progression mechanism. The effects of the xanthine derivative KMUP-1 on alleviating atherosclerosis and cardiac remodeling, as well as its underlying mechanisms, were examined. In this study, atherosclerosis and cardiac damage were induced in ApoE knockout (KO) mice by feeding them a high-fat diet (HFD) for 12 weeks. The co- and posttreatment of KMUP-1 was evaluated. Our results showed that KMUP-1 treatment significantly reduced body weight gain in HFD-induced mice. The Oil Red O and hematoxylin-eosin staining showed that KMUP-1 reduced the aortic plaque area, intima-media thickness, and intima-lumen thickness. KMUP-1 reduced inflammatory cytokines IL-1
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