ArticleCureus2025
Fatal Postoperative Pulmonary Tumor Thrombotic Microangiopathy: A Rare and Fulminant Complication of Large Cell Lung Carcinoma.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Acute Cor Pulmonale Caused by Pulmonary Tumor Thrombotic Microangiopathy as the Initial Presentation of Multiple Myeloma: A Case Report.Pulmonary circulation · 2026Article
- Pulmonary tumor thrombotic microangiopathy associated with prostate cancer achieving over 10-year survival: a case report.International cancer conference journal · 2026Article
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pulmonary tumor thrombotic microangiopathy (PTTM) is a paraneoplastic pulmonary vascular process characterized by microscopic tumor emboli with fibrocellular intimal proliferation, causing rapid progressive pulmonary hypertension and right heart failure. We report a 72-year-old male with stage IIB large cell lung carcinoma who developed fulminant respiratory failure two months after curative-intent lobectomy, just prior to adjuvant chemotherapy. On presentation, he had multiorgan failure and disseminated intravascular coagulation with a markedly elevated D-dimer. Despite intensive supportive care, he died within hours. Autopsy confirmed PTTM with widespread tumor emboli occluding small pulmonary arteries and arterioles, together with previously unrecognized systemic metastases. This case illustrates that PTTM may precipitate catastrophic decompensation even soon after apparently curative surgery and supports maintaining a high index of suspicion for this syndrome in large cell lung carcinoma patients presenting with acute cardiorespiratory failure.
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