Evidence map›Paper›PMID 41194789›Full record

ArticleSurgical case reports2025

The First Case of Liver-Intestine En-Bloc Transplantation in Japan.

Hiroyuki Ogasawara, Kyohei Kasuda, Naruhito Takido, Ryusuke Saito, Yoshihiro Shono, Muneyuki Matsumura, Kengo Sasaki, Atsushi Fujio, Kazuaki Tokodai, Hironori Kudo and 3 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Surgical case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Hiroyuki OgasawaraDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Kyohei KasudaDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Naruhito TakidoDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Ryusuke SaitoDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Yoshihiro ShonoDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Muneyuki MatsumuraDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Kengo SasakiDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Atsushi FujioDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Kazuaki TokodaiDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Hironori KudoDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Michiaki UnnoDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Takashi KameiDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.
Motoshi WadaDepartment of Surgery, Graduate School of Medicine, Tohoku University, Sendai, Miyagi, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSimultaneous liver-intestine transplantation is indicated for intestinal failure associated liver disease (IFALD), which can be caused by conditions such as intestinal motility disorders or short bowel syndrome. Currently, the most common grafts for liver-intestine transplantation are multivisceral transplantation (MVT) grafts consisting of the liver, stomach, duodenum, pancreas, small intestine, and colon, or liver-intestine grafts derived from the MVT graft but without the stomach. However, at the time of transplantation in the present case, Japanese regulations did not permit simultaneous pancreas transplantation in a non-diabetic recipient, which is generally required for this type of graft. Therefore, in the 2 previously reported domestic cases, the liver and intestine grafts were transplanted separately as non-composite grafts. Early in the development of MVT, liver-intestine grafts, excluding the stomach, duodenum, and pancreas, were used. We adopted this graft configuration for a 14-year-old female with megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) complicated by IFALD and performed, for the 1st time in Japan, a composite liver-intestine transplantation under existing regulations. CASE PRESENTATION: The patient was a 14-year-old female who was maintained on minimal enteral feeding via an intestinal stoma and parenteral nutrition because of MMIHS. Since approximately year X-7, her IFALD progressed, leading to portal hypertension with gastrointestinal bleeding and hypersplenism, which led to a significant decline in her quality of life. She was listed for deceased donor liver-intestine transplantation and a suitable donor became available in December X. The stomach, duodenum, and pancreas of the donor were resected

conclusionsWe report successful composite liver-intestine transplantation using a graft that excluded the stomach, duodenum, and pancreas, which led to good clinical outcomes.

Indexed as

composite liver–intestine transplantationintestinal failure associated liver disease (IFALD)megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS)multivisceral transplantationpediatric transplantation

Identifiers

PMID41194789
PMCPMC12583225

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.