ArticleObstetrics & gynecology science2025
Obstetric and perinatal outcomes in twin pregnancies conceived via assisted reproductive technology vs. spontaneous conception: a population-based cohort study.
Article in Obstetrics & gynecology science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Refractory Acquired Thrombotic Thrombocytopenic Purpura in the Third Trimester of Twin Pregnancy: A Case Report.International medical case reports journal · 2026Article
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5 authors.
Funding
Abstract
objectiveTo compare obstetric and perinatal outcomes between assisted reproductive technology (ART)-conceived and spontaneously conceived twin pregnancies using a nationwide Korean cohort.
methodsThis retrospective cohort study used Korean National Health Insurance Service data from October 2017 to December 2021. Twin pregnancies were identified via International Classification of Diseases, 10th revision codes and classified by conception type based on embryo transfer procedure codes. Outcomes included miscarriage, preeclampsia, placenta previa, gestational diabetes mellitus (GDM), emergency cesarean section (CS), intrauterine growth restriction (IUGR), and macrosomia. Multivariable logistic regression was used to calculate adjusted odds ratios (aORs), controlling for maternal age and comorbidities. Subgroup analyses stratified by maternal age were also performed.
resultsAmong 36,013 twin pregnancies, those conceived via ART showed higher risks of placenta previa (aOR, 1.81; 95% confidence interval [CI], 1.57-2.08), preeclampsia (aOR, 1.31; 95% CI, 1.17-1.47), GDM (aOR, 1.32; 95% CI, 1.22-1.43), emergency CS (aOR, 1.21; 95% CI, 1.08-1.34), and IUGR (aOR, 1.18; 95% CI, 1.07-1.31). In women ≥35 years, risks were more pronounced for preeclampsia (aOR, 1.38; 95% CI, 1.19-1.61) and emergency CS (aOR, 1.22; 95% CI, 1.06-1.42).
conclusionTwin pregnancies conceived via ART are associated with significantly increased risks of obstetric and perinatal complications compared with spontaneous conceptions. Given the growing utilization of ART, these findings underscore the importance of individualized prenatal care and vigilant perinatal monitoring in ART-conceived twin pregnancies, particularly among women of advanced maternal age.
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