Evidence map›Paper›PMID 41194438›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

DFT-Guided Design of a Multi-Enzyme Mimetic High-Entropy Nanozyme for Cascaded Glutathione Detection and Point-of-Care Testing.

Hua Lin, Li Ke, Shuran Wang, Ruoke Li, Shengmin Zhou, Yueling Liu, Huan Pang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hua LinState Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Li KeState Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Shuran WangState Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Ruoke LiState Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Shengmin ZhouState Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, P. R. China.
Yueling LiuState Key Laboratory of Bioreactor Engineering, School of Biotechnology, East China University of Science and Technology, Shanghai, 200237, P. R. China.ORCID https://orcid.org/0000-0001-7595-3293
Huan PangSchool of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu, 225009, P. R. China.ORCID https://orcid.org/0000-0002-5319-0480

Funding

National Natural Science Foundation of China 21804043State Key Laboratory of Life Science SKLACLS2512
6 · The paper itself

Abstract

Despite of the various advantages of Prussian blue analogs (PBA), most of the previous studies rely on conventional empirical and trial-and-error methods for identifying the effective catalytic activity. Theory-guided design using predictive models is leading a new revolution in the field of nanozymes, which has yet to focus on PBA. Herein, a series of PBAs, including binary, ternary, quaternary, quinary, and high-entropy, are first investigated by density functional theory (DFT) calculations. Both DFT and experimental results prove the superior catalytic activity of high-entropy than medium- and low-entropy PBAs, mainly owing to the enhanced d-band centers near the Fermi energy level (E

Indexed as

Biosensing TechniquesGlutathionePoint-of-Care TestingBenzidinesCatalysisColorimetryDensity Functional TheoryEntropyFerrocyanidesHydrogen Peroxide3,3',5,5'-tetramethylbenzidineBenzidinesFerrocyanidesGlutathioneHydrogen Peroxidecolorimetricglutathionehigh‐entropy nanozymemicrofluidic paperPrussian blue analogues

Identifiers

PMID41194438
PMCPMC12822477

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.