Evidence map›Paper›PMID 41194422›Full record

ArticleDrug delivery2025

Transcranial ultrasound combined with intravenous metformin-loaded oxygenated microbubbles attenuates noise-induced hearing loss in mice.

Ai-Ho Liao, Chih-Hung Wang, Lin-Yi Chou, Yu-Chan Hung, Yi-Chun Lin, Ho-Chiao Chuang, Kuo-Hsing Ma, Hao-Li Liu, Jehng-Kang Wang, Cheng-Ping Shih

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ai-Ho LiaoGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Chih-Hung WangDepartment of Otolaryngology, Taipei City Hospital, Taipei, Taiwan.
Lin-Yi ChouGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Yu-Chan HungGraduate Institute of Biomedical Engineering, National Taiwan University of Science and Technology, Taipei, Taiwan.
Yi-Chun LinDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.
Ho-Chiao ChuangDepartment of Mechanical Engineering, National Taipei University of Technology, Taipei, Taiwan.
Kuo-Hsing MaDepartment of Biology and Anatomy, National Defense Medical University, Taipei, Taiwan.
Hao-Li LiuDepartment of Electrical Engineering, National Taiwan University, Taipei, Taiwan.
Jehng-Kang WangDepartment of Biochemistry, National Defense Medical University, Taipei, Taiwan.
Cheng-Ping ShihDepartment of Otolaryngology-Head and Neck Surgery, Tri-Service General Hospital, National Defense Medical University, Taipei, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Noise-induced hearing loss (NIHL) involves a biphasic pathophysiology. Intense noise exposure causes immediate cochlear vasoconstriction and ischemia, leading to transient hypoxia. Subsequent reperfusion triggers excess reactive oxygen species (ROS) production, resulting in oxidative stress and hair cell injury. This study therefore developed two oxygenated albumin microbubble (OMB) formulations-ionic-bond metformin-coated (iMet-OMBs) and covalent-bond metformin-encapsulated (cMet-OMBs)-and combined them with transcranial ultrasound (US) to enhance targeted delivery to the cochlea. This approach aims to provide transient oxygen supplementation while simultaneously reducing ROS-mediated injury. Microbubbles were characterized for morphology, oxygen loading, and metformin content. Based on their superior stability and drug-loading profile, cMet-OMBs were selected for

Indexed as

Hearing Loss, Noise-InducedMetforminMicrobubblesOxygenAnimalsCochleaDisease Models, AnimalEvoked Potentials, Auditory, Brain StemHair Cells, Auditory, OuterMaleMiceMice, Inbred C57BLOxidative StressReactive Oxygen SpeciesMetforminOxygenReactive Oxygen SpeciesBlood–labyrinthine barrierhearing lossischemiametforminoxidative stressoxygenated microbubblesultrasound

Identifiers

PMID41194422
PMCPMC12599344

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.