Evidence map›Paper›PMID 41194418›Full record

ArticleEpigenomics2025

Differential microRNA profiling of blood L1CAM and bulk extracellular vesicles in bipolar disorder.

Gabriel R Fries, Salahudeen Mirza, Jun Wang, Camila N C Lima, Wei Zhang, Marcela Carbajal Tamez, Giselli Scaini, Jair C Soares, Joao Quevedo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epigenomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Gabriel R FriesTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-5468-2612
Salahudeen MirzaChild Study Center, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0001-7530-0591
Jun WangDepartment of Molecular and Human Genetics, Baylor College of Medicine Houston, TX, USA.
Camila N C LimaTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Wei ZhangTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.
Marcela Carbajal TamezCenter for Interventional Psychiatry, Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0009-0000-1116-8771
Giselli ScainiTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-9880-0887
Jair C SoaresCenter of Excellence in Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0002-5466-5628
Joao QuevedoTranslational Psychiatry Program, Faillace Department of Psychiatry and Behavioral Sciences, The University of Texas Health Science Center at Houston, Houston, TX, USA.ORCID 0000-0003-3114-6611

Funding

Deciphering the role of neuronal and peripheral DNA methylation in suicide and bipolar disorderK01MH121580 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI FRIES, GABRIEL RODRIGO · 2020 to 2023
$699k
Neural-derived extracellular vesicles microRNAs in bipolar disorder: a peripheral window into the brainR21MH117636 · NIMH · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI DE QUEVEDO, JOAO L · 2019 to 2020
$387k
NIMH NIH HHS K01 MH121580NIMH NIH HHS R21 MH117636
6 · The paper itself

Abstract

objectiveThis preliminary study aimed to identify microRNA (miRNA) signatures associated with bipolar disorder (BD) by profiling blood-derived extracellular vesicles (EVs) of both putative neuronal origin and from all sources.

methodIn two parallel studies of individuals with BD and controls (CON), we characterized miRNA expression profiles of blood EVs selected for L1CAM, a putative marker of neuronal origin (

resultsResults of Study 1 showed 34 miRNAs differentially expressed between groups and implicated PTEN, a gene whose protein levels were previously found to be altered in postmortem brain studies of BD. Results of Study 2 showed 10 miRNAs differentially expressed between groups. Limited overlap was identified between studies, with only hsa-miR-1-3p identified with the same direction of change across both types of EVs. Differentially expressed miRNAs were significantly associated with clinical features of BD only in Study 1.

conclusionsOur results, albeit preliminary, reiterate a crucial role for miRNAs in the pathophysiology of BD and suggest that miRNA signatures of putative neuronal origin may more closely correspond to clinical features.

Indexed as

Bipolar DisorderExtracellular VesiclesMicroRNAsNeural Cell Adhesion Molecule L1AdultBiomarkersCase-Control StudiesFemaleGene Expression ProfilingHumansMaleMiddle AgedBiomarkersL1CAM protein, humanMicroRNAsNeural Cell Adhesion Molecule L1biomarkerBipolar disorderdepressionepigeneticsextracellular vesiclesmaniamicroRNA

Identifiers

PMID41194418
PMCPMC12771548

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.