Evidence map›Paper›PMID 41194407›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Macrophage-Targeted Magnesium Ion-Nourisher for NLRP3 Inflammasome Inhibition to Enhance Liver Inflammatory Disease Treatment.

Li Wang, Zhuo Yan, Sindhu Yalavarthi, Yusif Abdul-Rashid, Kiki Parker, Kyle Nowlin, Ethan Li, Jordan Mack, Josephine Wei, Hunter Vu and 4 more

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Li WangDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Zhuo YanJoint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Sindhu YalavarthiDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Yusif Abdul-RashidDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Kiki ParkerDepartment of Nanoengineering, North Carolina Agricultural and Technical State University, Greensboro, NC, 27401, USA.
Kyle NowlinDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Ethan LiDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Jordan MackDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Josephine WeiDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Hunter VuDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Zhenquan JiaDepartment of Biology, University of North Carolina at Greensboro, Greensboro, NC, 27412, USA.
Jianjun WeiDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.
Jilong WangJoint Centre of Translational Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, Zhejiang, 325000, China.
Kerui WuDepartment of Nanoscience, Joint School of Nanoscience and Nanoengineering, University of North Carolina at Greensboro, Greensboro, NC, 27401, USA.ORCID https://orcid.org/0000-0002-5504-8875

Funding

Lung Cancer Initiative 1192550National Science Foundation ECCS-2025462North Carolina Biotechnology Center 2024-FLG-0066North Carolina Biotechnology Center 2024-FLG-0078
6 · The paper itself

Abstract

Magnesium (Mg) exerts important functions in immune regulation. Fluctuations of Mg levels significantly impact immune cell behavior, such as differentiation and inflammatory phenotypes of macrophages. However, exploiting Mg as an immunomodulatory intervention is challenging due to its unclear mechanism and broad impact across diverse cells. To overcome this, a nanosized Mg ion-nourisher is engineered, termed MgC

Indexed as

InflammasomesInflammationLiver DiseasesMacrophagesMagnesiumNLR Family, Pyrin Domain-Containing 3 ProteinAnimalsHumansLiverMiceMice, Inbred C57BLInflammasomesMagnesiumNLR Family, Pyrin Domain-Containing 3 Proteininflammationmacrophagemagnesium nano‐nourisherNLRP3 inflammasomestem cell‐derived vesicles

Identifiers

PMID41194407
PMCPMC12850138

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.