ArticleVirology journal2025
The increased expression levels of human endogenous retrovirus-K envelope and human endogenous retrovirus-H polymerase transcripts in laryngeal squamous cell carcinoma.
Article in Virology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Dynamics of Human Endogenous Retroviruses Expression, Proviral Load and Systemic Inflammatory Status Modulated by Physical Exercise and Aging.International journal of molecular sciences · 2026Article
- Metabolic crosstalk between oral microbiota and the host in OSCC: emerging roles of microbial metabolites in tumor initiation and progression.Frontiers in cellular and infection microbiology · 2026Review
- Activation of endogenous retroviruses in tumor cells and their immunomodulatory mechanisms: from molecular basis to clinical translation.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Laryngeal squamous cell carcinoma (LSCC) is a significant subtype of head and neck cancers, with tobacco and alcohol being primary risk factors. Many studies have shown that human endogenous retroviruses (HERVs), specifically HERV-K and HERV-H, have been implicated in the development and progression of various cancers, including head and neck cancers; nevertheless, there is a lack of research on the expression levels of HERV-K and HERV-H in LSCC. In this research, the differential expression of HERV-K Rec, Env, Np9, and HERV-H pol transcripts was assessed in 144 laryngeal biopsy specimens (72 polyps and 72 LSCC samples) utilizing quantitative Real-time PCR. The results showed a significant upregulation of HERV-K Env and HERV-H pol in the LSCC group compared to the polyp group (p < 0.001), suggesting their potential role in LSCC progression. The ROC curve analysis further supported the diagnostic significance of HERV-H pol and HERV-K Env transcripts in distinguishing LSCC from noncancerous polyps (HERV-H pol: AUC = 0.86; HERV-K Env: AUC = 0.76). Moreover, being over 50 years old and having an opium addiction were linked to increased expression levels of HERV-H Pol and HERV-K Env, suggesting a potential connection between these elements and laryngeal cancer (p < 0.001). These results highlight the possible utility of HERV-H pol and HERV-K Env as biomarkers for the diagnosis and prognosis of LSCC. Undoubtedly, additional research is imperative to establish the clinical efficacy of these biomarkers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.