ArticleBMC neurology2025
Circadian modulation of surgical timing and postoperative outcomes in subarachnoid hemorrhage: a retrospective cohort analysis.
Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSubarachnoid hemorrhage (SAH) is a devastating cerebrovascular emergency with mortality exceeding 30%. Emerging evidence underscores the role of circadian rhythms as critical modulators of cerebrovascular pathophysiology. Building upon recent studies identifying the BMAL1 (Brain and Muscle ARNT-Like 1)-HIF2A (Hypoxia-Inducible Factor 2 Alpha) axis as a key regulator of hypoxia-driven vascular injury, this study investigates the influence of circadian timing of surgery (Time1) and disease onset (Time2) on SAH outcomes-a novel approach integrating molecular insights with clinical practice.
methodsThis retrospective study analyzed 279 patients with anterior circulation SAH admitted to the Neurointensive Care Unit (NICU) at Liaoyang Central Hospital (2018-2024). Surgical (Time1) and symptom onset (Time2) times were categorized into four 6-hour intervals. Prognostic outcomes (good/poor at 6 months) were assessed using multivariable logistic regression, validated via the Akaike Information Criterion (AIC) and residual analysis.
resultsNocturnal surgery (21:00-03:00) demonstrated a non-significant trend toward reduced risk of poor prognosis (odds ratio [OR] = 0.56, P = 0.097). Onset time showed no significant association (P = 0.847). The addition of Time2 to the model increased the AIC (from 82.69 to 84.65), suggesting reduced model fit or potential overfitting. Residuals were normally distributed.
conclusionNocturnal surgery may confer neuroprotection, while onset time appears prognostically insignificant. Further mechanistic investigations are warranted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.