ArticleBMC pediatrics2025
Prognostic factors for long-term survival in Wilms tumor: a retrospective study.
Article in BMC pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundWilms tumor (WT) is the most common renal tumor in children, with prognosis varying widely due to multiple factors. This study aims to identify key prognostic factors in WT, with a particular focus on pathological grade.
methodsWe retrospectively analyzed 186 WT patients diagnosed between 2000 and 2021 using SEER database. Clinical and pathological factors such as age, tumor grade, and SEER stage were assessed for their impact on overall survival (OS) and cancer-specific survival using Cox regression models. The SEER stage was categorized as localized, regional, or distant. A nomogram was developed based on these factors to predict 1-, 3-, and 5-year OS, and its predictive accuracy was evaluated.
resultsOf the total, 94 patients had grade I-III tumors, while 92 had grade IV tumors. Univariate analysis revealed that older age (p < 0.001), higher grade (p = 0.011), distant metastasis (p < 0.001), and larger tumor size (p = 0.025) were associated with poorer prognosis. Multivariate analysis confirmed age at diagnosis (p < 0.001), tumor grade (p = 0.008), and stage (p = 0.004) as independent prognostic factors for OS. In the grade IV subgroup, patients had a higher rate of distant metastasis (37.0%), which significantly worsened their prognosis (p = 0.004). The nomogram demonstrated a strong predictive accuracy, with a C-index of 0.796 and AUC values of 0.886, 0.790, and 0.835 for predicting 1-, 3-, and 5-year overall survival, respectively. Calibration and decision curve analyses further validated the model’s reliability.
conclusionWT prognosis is closely associated with age, tumor grade, and SEER stage. The nomogram developed in this study serves as a reliable tool for predicting long-term survival in WT patients, aiding in clinical management and personalized treatment strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.