SynthesisBMC oral health2025
Association of periodontal disease with risk atrial fibrillation: systematic review.
Synthesis in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- From Periodontal Inflammation to Atrial Fibrillation: Molecular Links Through Thrombospondin-1, Galectin-3, and SGLT2-Related Pathways.International journal of molecular sciences · 2026Review
- The Interplay Between Periodontitis and Atrial Fibrillation: Inflammation as a Common Pathophysiological Bridge.International journal of molecular sciences · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontal disease (PD), a chronic inflammatory condition affecting nearly 50% of adults globally, drives systemic inflammation and cardiovascular diseases. Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, shares pathophysiological links with inflammation. This systematic review evaluates the association between PD and AF risk, addressing gaps in existing evidence.
methodsA comprehensive literature search was conducted in MEDLINE, EMBASE, and the Cochrane Library up to September 2025. Observational studies that met PICOS criteria (adults with/without PD, PD exposure, AF outcome) were included. Study quality was assessed using the Newcastle-Ottawa Scale (NOS). Data were synthesized narratively due to heterogeneity in PD/AF definitions.
resultsFour high-quality studies (NOS ≥ 6) were analyzed. All studies demonstrated a consistent association between PD and increased AF risk, with adjusted hazard ratios (HRs) ranging from 1.03 to 1.31. Severe PD showed stronger associations (HR: 1.31, 95% CI: 1.06–1.62), while PD recovery attenuated risk (HR: 1.00, 95% CI: 0.97–1.04). Mechanistically, PD-related systemic inflammation (e.g., elevated C-reactive protein) and pathogen translocation (e.g., Porphyromonas gingivalis) was implicated in atrial remodeling. Regular dental care was associated with reduced AF incidence.
conclusionPD is significantly associated with an elevated risk of AF, particularly in severe or persistent cases. The findings underscore PD as a modifiable risk factor, highlighting the potential of periodontal interventions in AF prevention.
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Registered trials
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