Evidence map›Paper›PMID 41194058›Full record

Trial reportBMC oral health2025

Effect of low-concentration at-home bleaching gels on whitening and tooth sensitivity: a split mouth randomized clinical trial.

Sijing Chu, Yizhou Wang, Zhonghua Duan, Pei Wu, Yuhua Wang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC oral health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sijing Chu *Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yizhou Wang *Department of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Zhonghua DuanDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Pei WuDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.
Yuhua WangDepartment of Prosthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China. WANGYH1707@sh9hospital.org.cn.

Funding

National Clinical Research Center for Oral Diseases, Shanghai, China NCRCO202332Natural Science Foundation of Shanghai Municipality 24ZR1443600Science and Technology Committee of Fengxian District, Shanghai, China FK20221402
6 · The paper itself

Abstract

objectiveTo assess the bleaching efficacy, tooth sensitivity, enamel surface morphology, and oral health-related quality of life (OHRQoL) of two at-home bleaching products with matched effective hydrogen peroxide (HP) concentrations: Beyke iWhite (8% carbamide peroxide) and Invisalign (3% hydrogen peroxide). MATERIALS AND

methodsA randomized, triple-blind, split-mouth clinical trial was conducted with 22 participants undergoing a two-week bleaching treatment. The gel was used daily for 6-8 h. Tooth color and OHRQoL were assessed at baseline, post-bleaching, and 1-month follow-up. Tooth color was measured using a spectrophotometer (ΔE

resultsBoth products presented effective color change (ΔE

conclusionsBoth products effectively whitened teeth while inducing mild tooth sensitivity, and both had a positive socio-psychological impact. The 3% HP gel provided a bleaching efficacy advantage, while the 8% CP gel demonstrated lower sensitivity and less enamel alteration. CLINICAL RELEVANCE: Clinicians may consider at-home bleaching techniques with 3% HP and 8% CP to obtain effective bleaching results with slight side effects.

trial registrationChinese Clinical Trial Registry ChiCTR2400092807, 24/11/2024, Retrospectively registered.

Indexed as

Dentin SensitivityHydrogen PeroxidePeroxidesTooth BleachingTooth Bleaching AgentsUreaAdultAnimalsCarbamide PeroxideCattleDental EnamelDouble-Blind MethodFemaleGelsHumansHydrogen-Ion ConcentrationCarbamide PeroxideGelsHydrogen PeroxidePeroxidesTooth Bleaching AgentsUreaCarbamide peroxideClinical trialDental bleachingEnamelHydrogen peroxide

Identifiers

PMID41194058
PMCPMC12746643

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.