ArticleBMC public health2025
Expanding diagnostic testing for drug-resistant tuberculosis in high burden settings: a cost-effectiveness analysis.
Article in BMC public health, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundNew and effective tools for detecting drug-resistant tuberculosis (DR-TB) include GeneXpert XDR and targeted Next Generation Sequencing (tNGS). However, data on their implementation in high TB-burden settings is limited. We aimed to determine cost-effectiveness of different strategies using GeneXpert XDR or tNGS for DR-TB detection in high TB-burden, low-resource settings.
methodsA dynamic simulation model was calibrated to WHO-reported TB data for Philippines and Thailand. Intervention scenarios for expanded diagnostic testing of drug-resistance were simulated for 2025 - 2035. Health benefits were estimated using disability-adjusted life years. Cost-effectiveness was calculated from a health system perspective using country-level TB diagnosis and treatment costs. Analyses include incremental cost-effectiveness ratios (ICERs) and incremental net monetary benefit (INMB).
resultsImplementing GeneXpert XDR or tNGS for DR-TB detection improves TB health outcomes. Scenarios using GeneXpert XDR are more likely to be cost-effective than scenarios using tNGS. Interventions targeting previously treated cases reduce costs but also reduce health benefits. Testing all TB cases with GeneXpert XDR is cost-effective (Philippines ICER = $1,808, INMB = $210M; Thailand ICER = $5,251, INMB = $26M) with a 1 x GDP willingness-to-pay threshold (WTP). Targeting GeneXpert XDR to previously treated cases is also cost-effective (Philippines ICER = $1,288, INMB = $52M; Thailand ICER = $3,667, INMB = $9.2M) but results in lower INMB. tNGS is cost-effective at higher WTP.
interpretationIn high TB-burden countries, GeneXpert XDR is cost-effective as an additional DR-TB diagnostic test. tNGS is not cost-effective for routine clinical DR-TB testing but has potential for application to high-risk populations, especially with introduction of new TB treatment regimens.
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