Joint association of nutritional and inflammatory status, and sedentary behavior on mortality in US adult cancer survivors: a population-based cohort study.

Tongzhe Zhao, Cheng Yang, Xueli Yang, Long Liang, Yunxiang Qi

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Article in BMC cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Tongzhe ZhaoChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Cheng YangSchool of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.

Xueli YangChengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.

Long LiangDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China.

Yunxiang QiDepartment of Radiation Oncology, Radiation Oncology Key Laboratory of Sichuan Province, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center, Affiliated Cancer Hospital of University of Electronic Science and Technology of China, Chengdu, China. q_yx416@126.com.

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6 · The paper itself

Abstract

backgroundThe interplay between nutritional and inflammatory status and sedentary behavior is intricate, and both are associated with the prognosis of cancer survivors. However, the combined effect of these factors on the mortality rate of cancer survivors remains unclear.

methodsWe selected cancer survivors from the National Health and Nutrition Examination Survey (2007-2018). The Naples Prognostic Score (NPS) was used as an integrated marker of inflammatory and nutritional status, while sedentary behavior was quantified based on self-reported daily sitting time. Multivariable Cox proportional hazards models were employed to examine the independent and combined associations of NPS and sedentary behavior with mortality outcomes in this population.

resultsAmong 2,411 cancer survivors followed for a median of 71 months, 554 deaths occurred (cancer, 190; non-cancer, 364). High NPS correlated with higher all-cause, cancer-specific, and non-cancer mortality. Longer sedentary time was independently linked to higher all-cause and non-cancer mortality, with each additional hour of sitting per day conferring a significant rise in risk. Survivors exhibiting both high NPS and ≥ 6 h/day of sedentary behavior faced the greatest mortality risks: all-cause (hazard ratio [HR] 4.44, 95% CI: 2.66-7.42), cancer-specific (HR 1.92 95% CI: 1.11-3.32), and non-cancer (HR 2.81, 95% CI: 1.76-4.50).

conclusionOur findings demonstrate that nutritional and inflammatory status and sedentary behavior collectively influence mortality risk in cancer survivors. Patients exhibiting concurrent poor nutrition, systemic inflammation (high NPS), and sedentary behavior may be at higher risk of death.

Indexed as

Cancer SurvivorsInflammationNeoplasmsNutritional StatusSedentary BehaviorAdultAgedCohort StudiesFemaleHumansMaleMiddle AgedNutrition SurveysPrognosisProportional Hazards ModelsUnited StatesCancer survivorsInflammationMortalityNaples prognostic scoreNHANESNutritionSedentary behavior

Identifiers

PMID41194025

DOI10.1186/s12885-025-15176-8

PMCPMC12590655

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