SynthesisBMC geriatrics2025
Dose-response effects of resistance training in sarcopenic older adults: systematic review and meta-analysis.
Synthesis in BMC geriatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review and meta-analysis of the effects of different exercise modalities on frailty in older adults.Frontiers in public health · 2026Pooled it
- Comparative effectiveness and dose-response relationship of exercise-based interventions for muscle mass in older women with sarcopenia: a systematic review and network meta-analysis.Frontiers in medicine · 2026Pooled it
- The Digital Transformation of Rehabilitation Medicine: A Narrative Review of Artificial Intelligence Innovations, Clinical Integration, and Future Paradigms.Journal of evaluation in clinical practice · 2026Review
- Trainability of repetitions-in-reserve estimation in younger and older adults: a parallel-group repeated-measures study.BMC sports science, medicine & rehabilitation · 2026Article
- Effects of different exercise types and intensities in older adults with sarcopenia: a systematic review and network meta-analysis.European geriatric medicine · 2026Review
- The Role of Exercise in Regulating Histone Modifications and Non-coding RNAs in Muscle Aging and Sarcopenia.Biochemical genetics · 2026Review
- Bone Mineral Density Findings Add Limited Novelty to Prior Meta-Analyses: A Comment on Shen Et al.Geriatrics & gerontology international · 2026Article
- Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCurrently, resistance training (RT) programs for sarcopenic older adults are numerous they remain controversial, and there is a lack of standardized programs specifically tailored for this population.
objectivesThis study aims to investigate the dose-response effects between RT on grip strength, skeletal muscle mass index (SMI), and short physical performance battery (SPPB) in sarcopenic older adults, to identify key training parameters in RT.
methodsA comprehensive search was conducted in databases including PubMed, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and WANFANG for randomized controlled trials published up to March 2025. Studies were selected based on the inclusion and exclusion criteria outlined in this study, resulting in 12 studies. The Grades of Recommendation, Assessment, Development, and Evaluation (GRADE) system was used to assess the quality of evidence, while Cochrane's Risk of Bias Tool evaluated the methodological quality of the included studies. Meta-analysis of baseline data and outcomes was performed using Review Manager version 5.3.4 and R version 3.5 software.
results12 studies involving 538 participants met the inclusion criteria. Compared to the control group, RT had a moderate effect on grip strength (SMD = 0.63, 95% CI 0.43-0.83; I² = 32%, X² = 11.73, df = 8, p < 0.00001) and SPPB (SMD = 0.56, 95% CI 0.18-0.94; I² = 53%, X² = 8.48, df = 4, p = 0.004) with in sarcopenic older adults, but it did not significantly improve SMI (SMD = 0.24, 95% CI -0.05-0.53; I² = 0%, X² = 2.85, df = 4, p = 0.10). Meta-regression analysis revealed that training frequency (p < 0.0001) and training intensity (p = 0.0019) were significant predictors of grip strength improvement, while training frequency (p = 0.052) may be a potential predictor for SPPB improvement. Additionally, subgroup analysis showed that incorporating pulling exercises into the training program significantly improved grip strength compared to studies that did not include such exercises (SMD = 0.90, 95% CI 0.61-1.19; I² = 0%, X² = 0.75, df = 2, p < 0.00001).
conclusionsOur meta-analysis suggests that RT is associated with improvements in grip strength and SPPB scores in sarcopenic older adults, whereas its effect on SMI was not statistically significant. The findings indicate that performing moderate-intensity resistance training twice a week is a promising strategy for improving grip strength, while a similar frequency may also benefit SPPB scores. Furthermore, incorporating pulling exercises into the RT regimen may positively influence grip strength outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.