Evidence map›Paper›PMID 41193983›Full record

ArticleBMC ophthalmology2025

Minimally invasive concretion-expulsion technique for primary canaliculitis: a prospective interventional study.

Chengmei Wang, Changxu Liu, Lin Wang, Honglin Wang, Zuoxiang Pang

Abstract read
In one paragraph

Article in BMC ophthalmology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Chengmei WangWeifang Eye Hospital, Zhengda Guangming Eye Group, 139 Xingfujie, Weifang City, Shandong Province, 261000, China.
Changxu LiuWeifang Pepole's Hospital, No. 151, Guangwen Street, Kuiwen District, Weifang City, Shandong Province, China.
Lin WangWeifang Eye Hospital, Zhengda Guangming Eye Group, 139 Xingfujie, Weifang City, Shandong Province, 261000, China.
Honglin WangWeifang Eye Hospital, Zhengda Guangming Eye Group, 139 Xingfujie, Weifang City, Shandong Province, 261000, China.
Zuoxiang PangWeifang Eye Hospital, Zhengda Guangming Eye Group, 139 Xingfujie, Weifang City, Shandong Province, 261000, China. pangzuoxiang@wfeye.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo prospectively evaluate a minimally invasive concretion-expulsion technique for primary canaliculitis that combines systematic canalicular milking with intracanalicular antibiotic therapy, establishing its efficacy and safety as a viable non-surgical alternative. MATERIALS AND

methodsThis prospective interventional study was conducted over a 36-month period (June 2020–June 2023), enrolling patients with PCC treated using the concretion-expulsion technique and followed for at least 12 months. The procedure involved gentle massage along the conjunctival aspect of the canaliculus to express concretions and secretions from the common canaliculus to the canalicular ampulla, followed by mechanical evacuation through the punctum. This process was repeated, with adjunctive gatifloxacin gel instillation to dislodge residual debris, until no secretions were visible. Tobramycin-dexamethasone ointment was then applied. Demographic data, clinical features, and outcomes were analyzed statistically.

resultsNinety patients (90 eyes) were included, with a male-to-female ratio of 22.2% (20) to 77.8% (70) and a mean age of 66.27 ± 14.15 years. Laterality included 42 right (46.67%) and 48 left (53.33%) eyes, with involvement of the lower canaliculus in 57 cases (63.3%), upper canaliculus in 27 (30%), and both in 6 (6.7%). All patients exhibited increased ocular discharge, with common symptoms including redness(88.89%), epiphora (77.78%), swelling(55.55%), foreign body sensation (11.11%), and pain (6.67%). Concretions were present in 85 patients (94.44%), alongside signs such as mucopurulent discharge (44.44%), medial canthal swelling (38.89%), punctal eversion (“pouting”,33.33%), conjunctival hyperemia (27.78%), canalicular dilation (22.22%), and obstruction (11.11%). The mean symptom duration was 16 ± 11.06 months. A total of 66.67% were cured after one expulsion session, with a mean of 1.9 ± 0.83 sessions required overall. Subgroup analyses (dry eye status, age < 70 vs. ≥70 years, gender, symptom duration < 15 vs. ≥15 months) revealed no significant differences in treatment frequency (P > 0.05 for all). Complete resolution of symptoms and clinical signs was observed in all patients by the final follow-up.

conclusionThe concretion-expulsion technique is a minimally invasive, safe, and effective approach that preserves the anatomical and functional integrity of the punctum and canaliculus, representing a viable treatment option for primary canaliculitis.

Indexed as

Anti-Bacterial AgentsCanaliculitisDacryocystitisMassageAdultAgedDexamethasoneFemaleHumansMaleMiddle AgedProspective StudiesTobramycinTreatment OutcomeAnti-Bacterial AgentsDexamethasoneTobramycinLacrimal canaliculitisMinimally invasive canaliculotherapyPrimary canaliculitis

Identifiers

PMID41193983
PMCPMC12587586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.