ArticleThe journal of headache and pain2025
Abnormal brain iron deposition in patients with new daily persistent headache: a prospective quantitative susceptibility mapping study.
Article in The journal of headache and pain, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Voxel-Wise Whole-Brain Analysis in Quantitative Susceptibility Mapping: A Narrative Review.Human brain mapping · 2026Review
- Subcortical nuclei and glymphatic system alterations in migraine with aura: a comparative 7T multimodal MRI analysis.The journal of headache and pain · 2025Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundThe underlying pathogenesis of New daily persistent headache (NDPH) is currently unknown. Abnormal iron deposition in specific brain regions has been reported to be associated with the pathogenesis of migraine. This study aimed to investigate the role of iron metabolism disorders in the pathogenesis of NDPH using quantitative susceptibility mapping (QSM).
methodsTwenty-five NDPH patients and 43 gender- and age-matched healthy controls (HCs) were recruited. 3D T1-weighted images (T1WI) and QSM sequences were performed at a 3.0 T MRI scanner. Voxel-based analysis was used to compare differences in iron content between NDPH and HC groups after QSM maps were normalized to the Montreal Neurological Institute space. The correlations between QSM values and clinical assessment scale scores were also assessed.
resultsThere were significant differences in iron levels in the right cerebellar lobule VIII, right insula, and left gyrus rectus between the NDPH patients and the HC group. Compared to the HC group, patients with NDPH showed higher iron deposition in these three regions. There was no significant correlation between the QSM values and the scores of the clinical scales in these three regions.
conclusionsOur findings indicated that the metabolic disorder of iron deposition in specific areas of the brain may be related to the underlying pathogenesis of patients with NDPH. These findings should be regarded as preliminary exploratory results, suggesting a possible involvement of iron metabolism in the mechanisms of NDPH, which requires further validation in subsequent studies.
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