ArticleBMC gastroenterology2025
Association between the blood urea nitrogen-albumin ratio and mortality in critically ill patients with gastrointestinal bleeding: a retrospective cohort study.
Article in BMC gastroenterology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Hourly Blood Urea Nitrogen Trajectories and ICU Mortality Risk in Critically Ill Patients with Gastrointestinal Bleeding: A Multicenter Retrospective Cohort Study.Advances in therapy · 2026Article
- Regional Differences Exist in Gender Representation Among GI Trainees and Faculty in the United States.Digestive diseases and sciences · 2026Article
- Prognostic Value of BUN-Based Ratios for Mortality and Prolonged Hospitalization in Acute Upper Gastrointestinal Bleeding: Comparison with Established Risk Scores.Medicina (Kaunas, Lithuania) · 2026Article
- Development and validation of a prognostic model incorporating the blood urea nitrogen-to-albumin ratio for predicting mortality in methicillin-resistant Staphylococcus aureus bloodstream infection.BMC infectious diseases · 2026Article
- Association between the blood urea nitrogen to albumin ratio and 30-day mortality in critically ill children with acute kidney injury.Scientific reports · 2026Article
- Red cell distribution width to albumin ratio (RAR) as a predictor of clinical outcomes and in-hospital mortality in acute gastrointestinal bleeding: a retrospective analysis.Proceedings (Baylor University. Medical Center) · 2026Article
- Systemic immune-inflammation index combined with blood urea nitrogen to albumin ratio predicts 28-day mortality in sepsis: a retrospective cohort study.Frontiers in physiology · 2026Article
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Authors and funding
8 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute gastrointestinal bleeding (GIB) represents a life-threatening medical emergency. This study investigates the prognostic utility of the Blood Urea Nitrogen-to-albumin ratio (BAR) in patients with GIB.
methodsPatients were stratified according to BAR levels. The association between BAR and 28-day and 1-year mortality was examined using Cox proportional hazards regression, restricted cubic splines (RCS), and Kaplan-Meier (KM) analysis. Comprehensive subgroup analyses were further conducted to evaluate consistency across clinically relevant strata.
resultsIn this study, a total of 1624 patients were included. Elevated BAR was an independent predictor of higher mortality at 28 days (HR 1.03, 95% CI 1.02-1.04) and 1 year (HR 1.02, 95% CI 1.01-1.03; both P < 0.001). Receiver Operating Characteristic (ROC) analysis indicated moderate discrimination for mortality prediction. Restricted cubic splines suggested a linear dose-response relationship between BAR and mortality. Significant interactions were observed with acute kidney injury (AKI) and continuous renal replacement therapy (CRRT). A nomogram incorporating BAR and other predictors achieved AUCs of 0.805 (0.779-0.832) for 28-day and 0.789 (0.765-0.814) for 1-year mortality.
conclusionThis study demonstrates that an elevated BAR independently predicts mortality in patients with GIB.
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