Evidence map›Paper›PMID 41193931›Full record

ArticlePharmacology research & perspectives2025

Intranasal Insulin Mitigates Memory Impairment and Neuroinflammation in a Mouse Model of Hippocampal Aging.

Rajasekar Nagarajan, Han Zhang, Jinrui Lyu, Maltesh Kambali, Muxiao Wang, Uwe Rudolph

Abstract read
In one paragraph

Article in Pharmacology research & perspectives, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rajasekar NagarajanDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Han ZhangDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Jinrui LyuDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Maltesh KambaliDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Muxiao WangDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.
Uwe RudolphDepartment of Comparative Biosciences, College of Veterinary Medicine, University of Illinois Urbana-Champaign, Urbana, Illinois, USA.

Funding

Cellular mechanisms for age-related cognitive dysfunction and its pharmacological reversal: a strategy towards prevention and treatment of postoperative cognitive deficits in elderly patientsR01GM128183 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI RUDOLPH, UWE · 2019 to 2022
$1.6M
Postoperative Neurocognitive Disorder - Strategies for Prevention or Reversal Based on Molecular ad Cellular MechanismsR35GM153232 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI Uwe Rudolph · 2024 to 2026
$1.3M
NIGMS NIH HHS R01 GM128183NIGMS NIH HHS R01GM128183NIGMS NIH HHS R35 GM153232NIGMS NIH HHS R35GM153232
6 · The paper itself

Abstract

Aging is a complex process that frequently includes cognitive decline with memory loss. In the hippocampus, the number of somatostatin-positive (Sst

Indexed as

AgingHippocampusInsulinMemory DisordersNeuroinflammatory DiseasesAdministration, IntranasalAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLMice, TransgenicSomatostatinInsulinSomatostatincGAS–STING pathwayGABAergic signalinghippocampusintranasal insulinsomatostatin‐positive interneurons

Identifiers

PMID41193931
PMCPMC12588873

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.