Evidence map›Paper›PMID 41193914›Full record

ReviewMicrobial biotechnology2025

Attenuated Strains of Pseudomonas aeruginosa: A Promising Cell Factory for Rhamnolipid Production.

Parvathy V Das, Meagan E Valentine, Timothy E Long, Hongwei D Yu

Abstract readReview
In one paragraph

Review in Microbial biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Parvathy V DasDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.ORCID 0000-0002-4562-3565
Meagan E ValentineDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.
Timothy E LongDepartment of Pharmaceutical Sciences, School of Pharmacy, Marshall University, Huntington, West Virginia, USA.ORCID 0000-0003-0213-4726
Hongwei D YuDepartment of Biomedical Sciences, Joan C. Edwards School of Medicine at Marshall University, Huntington, West Virginia, USA.ORCID 0000-0002-8546-0158

Funding

WV INBRE: The Inhibitor of Growth Family Member 4 (ING4) inhibits L-Type Amino Acid Transporter 1 (LAT1) expression to suppress Breast CancerP20GM103434 · NIGMS · MARSHALL UNIVERSITY · PI GARY O RANKIN · 2012 to 2026
$61.1M
Discovery of Disulfiram as an Anti-MRSA Antibiotic AdjuvantR15AI151970 · NIAID · MARSHALL UNIVERSITY · PI LONG, TIMOTHY EDWARD · 2020 to 2020
$434k
National Institute of Allergy and Infectious DiseasesNIAID NIH HHS R15 AI151970NIGMS NIH HHS P20 GM103434NIH HHS P20GM103434NIH HHS R15AI151970Stepan Company
6 · The paper itself

Abstract

Biodegradable compounds like rhamnolipids provide an environmentally friendly alternative to petroleum-based surfactants. Pseudomonas aeruginosa is the most proficient producer of rhamnolipids. The genetic plasticity and metabolic versatility of P. aeruginosa can be harnessed to leverage the production of rhamnolipids. However, P. aeruginosa carries virulence factors and can cause debilitating diseases in immunocompromised individuals. Bacteria other than P. aeruginosa have been used as heterologous hosts for rhamnolipid production through genetic engineering. Our lab had previously developed genetically attenuated strains of P. aeruginosa to produce polysaccharide alginate. These strains can also be used for rhamnolipid production. This review examines the unique genetic, biochemical, and physiological characteristics of P. aeruginosa amenable to be exploited via bioengineering and the existing models for rhamnolipid production. Further, we propose the attenuated strains of P. aeruginosa as a safe cell-factory for industrial production and biomedical use of rhamnolipids.

Indexed as

GlycolipidsMetabolic EngineeringPseudomonas aeruginosaGlycolipidsrhamnolipidPseudomonas aeruginosarhamnolipidssafe strain generation

Identifiers

PMID41193914
PMCPMC12588882

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.