Evidence map›Paper›PMID 41193901›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2026

Interpretive consistency of a qualitative

Ajith Antony, Nguyen H Tran, Nandakumar G Patnam, Kamaxi H Trivedi, Aashna Karbhari, Suman Garima, Sovanlal Mukherjee, Mark S Jacobson, Bradley J Kemp, Scott M Thompson and 1 more

Abstract readComparative Study
In one paragraph

Article in European journal of nuclear medicine and molecular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ajith AntonyDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Nguyen H TranDivision of Medical Oncology, Mayo Clinic, Rochester, MN, 55905, USA.
Nandakumar G PatnamDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Kamaxi H TrivediDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Aashna KarbhariDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Suman GarimaDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Sovanlal MukherjeeDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Mark S JacobsonDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Bradley J KempDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Scott M ThompsonDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA.
Ajit H GoenkaDepartment of Radiology, Mayo Clinic, Rochester, MN, 55905, USA. Goenka.ajit@mayo.edu.ORCID 0000-0002-7804-2695

Funding

Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Lila J. Rutten · 1985 to 2026
$151.3M
Optimizing Pancreatic Cancer Management with Next Generation Imaging and Liquid BiopsyR01CA256969 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Eric Collisson, Ajit Harishkumar Goenka · 2021 to 2026
$3.1M
Quantitative In Vivo 68Ga-Fibroblast-Activation-Protein-Inhibitors (FAPI)-46 PET Imaging of Cancer-Associated Fibroblasts (CAFs) in Pancreatic Ductal Adenocarcinoma (PDA)R01CA272628 · NCI · MAYO CLINIC ROCHESTER · PI GOENKA, AJIT HARISHKUMAR · 2022 to 2025
$2.5M
NCI NIH HHS P30 CA015083NCI NIH HHS R01 CA256969NCI NIH HHS R01 CA272628U.S. Department of Defense CA190188
6 · The paper itself

Abstract

purposeAccurate treatment response assessment in HCC is crucial but challenged by interpretive variability on CT/MRI. PSMA has emerged as a theranostic biomarker in HCC; however, interpretive reliability is a prerequisite for its validation against oncologic outcomes. Therefore, we evaluated interpretive consistency of a qualitative

methodsPatients with treatment-naïve HCC were prospectively enrolled for

resultsFrom 88 patients with baseline

conclusionA qualitative PSMA PET framework for HCC treatment response assessment yields nearly perfect interpretive consistency, outperforming CT/MRI-based criteria in post-ICI settings. These findings provide the foundation to validate PSMA-based response against oncologic outcomes in future clinical trials, a critical step toward guiding patient management and accelerating therapeutic innovation in HCC.

Indexed as

Carcinoma, HepatocellularEdetic AcidLiver NeoplasmsOligopeptidesPositron-Emission TomographyPositron Emission Tomography Computed TomographyAgedFemaleGallium IsotopesGallium RadioisotopesHumansMaleMiddle AgedReproducibility of ResultsTreatment OutcomeEdetic Acidgallium 68 PSMA-11Gallium IsotopesGallium RadioisotopesOligopeptidesBiomarkersHepatocellular carcinomaImmune checkpoint inhibitorsPositron emission tomography computed tomography, gallium 68 PSMA-11

Identifiers

PMID41193901
PMCPMC12883197

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.