ArticleBritish journal of cancer2026
Risk of malignant melanoma and colorectal cancer in Birt-Hogg-Dubé syndrome - a matched cohort study.
Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Comment on "Risk of malignant melanoma and colorectal cancer in Birt-Hogg-Dubé syndrome-a matched cohort study" by Skarin Nordenvall et al.British journal of cancer · 2026Article
- Substrate-selective mTORC1 regulation and gene dosage-dependent tissue divergence in Birt-Hogg-Dubé syndrome.Frontiers in oncology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
backgroundBirt-Hogg-Dubé syndrome (BHDS) is an autosomal dominant cancer predisposition syndrome, caused by pathogenic variants in FLCN, characterized by benign fibrofolliculomas, pulmonary cysts, pneumothorax, and increased risk for kidney tumors. To date, the risk of other solid tumors in individuals with BHDS remains unclear.
methodsWe performed a register-based matched cohort study of 353 Swedish born individuals with verified pathogenic variants in FLCN to study the association between BHDS and other cancer types than kidney tumors. Each patient was matched to 50 comparisons, matched by birth year, birth county and sex. Associations were estimated using Cox Proportional Hazard models, expressed as Hazard Ratios with 95% Confidence Intervals.
resultsPatients with BHDS exhibited a significantly elevated risk of adult cancer (adjusted HR 2.25, 95% CI 1.76-2.87), primarily driven by kidney tumors. Colorectal cancer and malignant melanoma were more prevalent in the BHDS cohort, reflected by a fivefold increase in risk of colorectal cancer (adjusted HR 5.44, 95% CI 2.74-10.81) and an almost threefold risk of malignant melanoma (adjusted HR 2.67, 95% CI 1.17-6.07).
conclusionThis study confirms the high risk of kidney tumors in BHDS and identifies increased risks for colorectal cancer and malignant melanoma, though the absolute risks remain low. Further research is needed to validate the colorectal cancer association and assess its implications for screening and management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.