ReviewNature2025
The new frontier in understanding human and mammalian brain development.
Abstract readReview
In one paragraph
Review in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Article
- A consensus atlas of human brain development defines cell type-specific maturation trajectories across the lifespan.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms coordinating exit from the stem cell state in mammals.Genes & development · 2026Review
- Article
- Article
- An Integrated Single-Cell and Epigenomic Resource for Comparative Analysis of the Basal Ganglia.bioRxiv : the preprint server for biology · 2026Article
- From the brain cell atlas to precision neurology: a review of the application of AI-driven multi-omics in brain science.GigaScience · 2026Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
39 authors.
Tomasz J NowakowskiDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA. Tomasz.nowakowski@ucsf.edu.ORCID 0000-0003-2345-4964
Patricia R NanoDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-5507-2656
Katherine S MathoChildren's Hospital Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-6105-4219
Xiaoyin ChenAllen Institute for Brain Science, Seattle, WA, USA.
Emily K CorriganThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-9072-7291
Wubin DingGenomic Analysis Laboratory, The Salk Institute for Biological Studies, La Jolla, CA, USA.ORCID 0000-0002-5355-7561
Yuan GaoAllen Institute for Brain Science, Seattle, WA, USA.
Matthew HeffelDepartment of Human Genetics, University of California Los Angeles, Los Angeles, CA, USA.
Jaikishan JayakumarCenter for Computational Brain Research, Sudha Gopalakrishnan Brain Centre, Indian Institute of Technology Madras, Chennai, India.ORCID 0000-0001-8925-723X
Harris S KaplanDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0002-8583-5714
Fae N KronmanDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0001-5201-6125
Rothem KovnerDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Camiel C A MannensMolecular Neurobiology Unit, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-1318-2603
Mengyi SongThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Marilyn R SteyertDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-4095-4776
Sridevi VenkatesanPhysiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.
Jenelle L WallaceThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Li WangThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-9510-6294
Jonathan M WernerPhysiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.
Di ZhangDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.
Guohua YuanDepartment of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA.
Guolong ZuoThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-1214-8849
Seth A AmentInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.ORCID 0000-0001-6443-7509
Carlo ColantuoniInstitute for Genome Sciences, University of Maryland School of Medicine, Baltimore, MD, USA.
Catherine DulacDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, MA, USA.ORCID 0000-0001-5024-5418
Rong FanDepartment of Biomedical Engineering, Yale University, New Haven, CT, USA.ORCID 0000-0001-7805-8059
Jesse GillisPhysiology Department and Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-0936-9774
Arnold R KriegsteinThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-5742-2990
Fenna M KrienenPrinceton Neuroscience Institute, Princeton University, Princeton, NJ, USA.ORCID 0000-0002-1400-6820
Yongsoo KimDepartment of Neuroscience and Experimental Therapeutics, College of Medicine, The Pennsylvania State University, Hershey, PA, USA.ORCID 0000-0002-4277-0279
Sten LinnarssonMolecular Neurobiology Unit, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden.ORCID 0000-0002-3491-3444
Partha P MitraCold Spring Harbor Laboratory, Cold Spring Harbor, NY, USA.
Alex A PollenThe Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
Nenad SestanDepartment of Neuroscience, Yale School of Medicine, New Haven, CT, USA.ORCID 0000-0003-0966-9619
Daniel J TwardDepartment of Computational Medicine, University of California Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-4607-6807
Cindy T J van VelthovenAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0001-5120-4546
Zizhen YaoAllen Institute for Brain Science, Seattle, WA, USA.ORCID 0000-0002-9361-5607
Aparna BhaduriDepartment of Biological Chemistry, University of California Los Angeles, Los Angeles, CA, USA. ABhaduri@mednet.ucla.edu.ORCID 0000-0003-4625-6899
Hongkui ZengAllen Institute for Brain Science, Seattle, WA, USA. HongkuiZ@alleninstitute.org.ORCID 0000-0002-0326-5878
Funding
Generation of novel cell type specific mouse genetic toolsU19MH114830 · NIMH · ALLEN INSTITUTE · PI NGAI, JOHN J. · 2017 to 2021
$64.7MComprehensive single-cell atlas of the developing mouse brainU01MH130962 · NIMH · HARVARD UNIVERSITY · PI Paola Arlotta, Tomasz Nowakowski · 2022 to 2026
$33.3MA Multidisciplinary Center for Developing Human and Non-human Primate Brain Cell AtlasesUM1MH130991 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Hao Huang, ARNOLD KRIEGSTEIN · 2022 to 2026
$25.2MEstablishing Common Coordinate Framework for Quantitative Cell Census in Developing Mouse BrainsRF1MH124605 · NIMH · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI GEE, JAMES C, KIM, YONGSOO · 2020 to 2020
$3.8MNeurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disordersR01MH128364 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tomasz Nowakowski, JOHN L. R. RUBENSTEIN · 2023 to 2026
$3.0MDevelopmental Timing During Cortical DevelopmentR01NS123263 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Tomasz Nowakowski · 2022 to 2026
$2.1MElucidating Regulation of Cell Fate Specification in Human Cortical Development to Understand Etiology of Neurodevelopment DisordersR01MH132689 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aparna Bhaduri · 2024 to 2026
$2.1MUnderstanding Brain Development Through the Lens of MetabolismR00NS111731 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BHADURI, APARNA · 2021 to 2023
$738kNIMH NIH HHS R01 MH128364NIMH NIH HHS R01 MH132689NIMH NIH HHS RF1 MH124605NIMH NIH HHS U01 MH130962NIMH NIH HHS U19 MH114830NIMH NIH HHS UM1 MH130991NINDS NIH HHS R00 NS111731NINDS NIH HHS R01 NS123263
Abstract
Neurodevelopmental disorders that cause cognitive, behavioural or motor impairments affect around 15% of children and adolescents worldwide
Indexed as
BrainMammalsAnimalsAtlases as TopicHumansMiceNeurodevelopmental Disorders
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.