Evidence map›Paper›PMID 41193839›Full record

ArticleProtoplasma2026

Chemical, biological, morphological, and anatomical exploration of Tripleurospermum monticolum Born. (Asteraceae): A promising medicinal plant.

Hatice Rümeysa Sönmez, Şeydanur Karakaş, Ayşe Civaş, Ayşe Cemre Kararenk, Elif Beyza Özer, Enes Tekman, Hafize Yuca, Mehmet Bona, Furkan Çoban, Aydan Acar Şahin and 6 more

Abstract read
PubMed Publisher
In one paragraph

Article in Protoplasma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Hatice Rümeysa SönmezDepartment of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0003-0181-9424
Şeydanur KarakaşDepartment of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0009-0009-9563-0526
Ayşe CivaşDepartment of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0002-8838-3856
Ayşe Cemre KararenkDepartment of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0009-0007-2058-9798
Elif Beyza ÖzerDepartment of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0001-7484-1126
Enes TekmanDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0002-1226-7218
Hafize YucaDepartment of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0002-0857-4776
Mehmet BonaDepartment of Botany, Faculty of Science, Istanbul University, Istanbul, Türkiye.ORCID http://orcid.org/0000-0003-1656-2641
Furkan ÇobanDepartment of Field Crops, Faculty of Agriculture, Atatürk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0003-2815-8988
Aydan Acar ŞahinFaculty of Science, Department of Biology, Ankara University, Ankara, Türkiye.ORCID http://orcid.org/0000-0002-5350-5534
Nur Münevver PınarFaculty of Science, Department of Biology, Ankara University, Ankara, Türkiye.ORCID http://orcid.org/0000-0001-5466-795X
Mohaddeseh NobarirezaeyehDepartment of Pharmacognosy, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0002-2722-6910
Gülnur Ekşi BonaDepartment of Pharmaceutical Botany, Faculty of Pharmacy, İstanbul- Cerrahpaşa University, İstanbul, Türkiye.ORCID http://orcid.org/0000-0002-6869-8703
Betül DemirciDepartment of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0003-2343-746X
Gamze GögerDepartment of Pharmacognosy, Faculty of Pharmacy, Afyonkarahisar Healt Science University, Erzurum, Türkiye.ORCID http://orcid.org/0000-0003-2978-5385
Songul KarakayaDepartment of Pharmaceutical Botany, Faculty of Pharmacy, Ataturk University, Erzurum, Türkiye. snglkarakaya@yahoo.com.ORCID http://orcid.org/0000-0002-3268-721X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus and Alzheimer's disease are interconnected, with type 2 diabetes raising dementia risk. Decoctions and infusions of Tripleurospermum monticolum (Asteraceae) are traditionally used to treat cough, stomachaches, and fever, while its flowers are commonly brewed into tea to alleviate stomach discomfort. The study examined the inhibitory effects of methanol and aqueous extracts from T. monticolum (capitulum, root, and aerial parts) on key enzymes (acetylcholinesterase, butyrylcholinesterase, α-amylase, and α-glucosidase) and assessed antioxidant activity, as well as the total phenolics, flavonoids, and tannins. Essential oils were analyzed via GC-MS/MS, and morphological, anatomical, and metabolite tests were also performed. In the essential oil of the capitulum, (2Z,8Z)-matricaria ester (64.1%) is the dominant compound, while the aerial part is rich in pentacosane (22.2%) and caryophyllene oxide (13.5%). The root, on the other hand, contains high levels of geranyl isovalerate (30.7%). The aerial part methanol extract showed the highest phenolic (74.686 µg GAE/mg), flavonoid (259.083 µg RE/mg), and tannin (83.000 µg TAE/mg) contents. Root methanol extract had the strongest 2,2-Diphenyl-1-picrylhydrazyl radical (DPPH

Indexed as

AnticholinesteraseAntidiabeticAntimicrobialAntioxidantTripleurospermum monticolum

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.