Evidence map›Paper›PMID 41193819›Full record

ArticlePediatric research2026

Effects of platelet transfusions on neonatal bleeding and inflammation.

Patricia Davenport, Henry A Feldman, Vanessa Young, Erin Soule-Albridge, Rylee Kerper, Stephanie Kinlay, Emily Nolton, Ashley Stoeckel, Frederik Denorme, Mark J Cody and 4 more

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In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Probiotic-associated Bacillus subtilis subsp. subtilis catheter-related bloodstream infection in a preterm infant: a caution for neonatal intensive care units.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Patricia DavenportDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA. Patricia.davenport@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-1230-504X
Henry A FeldmanDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Vanessa YoungDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Erin Soule-AlbridgeDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Rylee KerperDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Stephanie KinlayDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Emily NoltonDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.
Ashley StoeckelDepartment of General Surgery, Boston Children's Hospital, Boston, MA, USA.
Frederik DenormeDepartment of Emergency Medicine, Washington University, St. Louis, MO, USA.
Mark J CodyDivision of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Erika Marques de MenezesVitalant Research Institute, San Francisco, CA, USA.
Philip NorrisVitalant Research Institute, San Francisco, CA, USA.
Christian C YostDivision of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.
Martha Sola-VisnerDivision of Newborn Medicine, Boston Children's Hospital, Boston, MA, USA.

Funding

THE RoLE OF NEONATAL ANEMIA IN LEARNING AND MEMORYP01HL046925 · NHLBI · UNIVERSITY OF IOWA · PI JOSEPHSON, CASSANDRA D · 1992 to 2022
$34.3M
NHLBI NIH HHS P01 HL046925
6 · The paper itself

Abstract

backgroundPlatelet transfusions are frequently given to preterm neonates. However, observational and randomized studies have reported higher morbidity and mortality associated with increased numbers of transfusions. We hypothesized that this was related to pro-inflammatory effects of transfused platelets. This study assessed the effects of platelet transfusions on bleeding, plasma cytokines, and neutrophil extracellular trap (NET) levels in neonates.

methodsThis was a prospective cohort study of thrombocytopenic neonates conducted from 2020 to 2024. Bleeding was assessed with each platelet count. Blood was collected before and 2 h or 4 h after platelet transfusion for evaluation of a plasma cytokine panel and NETs. Aliquots from transfused units were also collected.

resultsForty-two infants with severe thrombocytopenia received 68 platelet transfusions. Transfusion increased the platelet count by 15 ± 3 × 10

conclusionsPlatelet transfusions are associated with increases in inflammatory cytokines and NET in neonates, which may contribute to the negative outcomes associated with platelet transfusions. IMPACT: In a recent randomized trial, liberal platelet transfusions were associated with increased bleeding and/or mortality in preterm neonates. We hypothesized that these findings would be related to the pro-inflammatory effects of platelet transfusions. In a cohort of thrombocytopenic neonates, platelet transfusions were associated with increases in RANTES, a potent chemokine, and neutrophil extracellular traps (NETs). The transfused platelet units' storage time and free mitochondrial DNA concentration correlated with the RANTES increase. This study identified novel transfusion-related inflammatory changes in neonates, which may contribute to the observed outcomes, and Blood Banking factors that might influence these effects.

Indexed as

HemorrhageInflammationPlatelet TransfusionThrombocytopeniaChemokine CCL5CytokinesDNA, MitochondrialExtracellular TrapsFemaleHumansInfant, NewbornMalePlatelet CountProspective StudiesChemokine CCL5CytokinesDNA, Mitochondrial

Identifiers

PMID41193819

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.