ArticleNature2025
Lymphoid gene expression supports neuroprotective microglia function.
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In one paragraph
Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22citing papers in PubMed
–field-weighted citation impact
What it found
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Who cites it
22 citing papers in PubMed.
- Targeting Microglial Transcriptional Reprogramming as a Therapy Strategy for Alzheimer's Disease.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026Review
- Review
- Microglia prune developing cortical blood vessels through PD-1 signaling.Nature neuroscience · 2026Article
- Unraveling Neurodegeneration: Common Molecular Mechanisms and Novel Therapeutic Concepts in Major Neurodegenerative Disorders.Brain and behavior · 2026Review
- Article
- Reshaping the immune landscape: next-generation microglia-targeted therapies for Alzheimer's disease.Biological research · 2026Review
- Lymphoid-like Suppressive Microglia in Alzheimer's Disease: A New Neuroimmune Regulatory Axis?Cells · 2026Review
- Glial cells in chronic inflammation: diversity, dysfunction and therapeutic targeting.Nature reviews. Immunology · 2026Review
- Microglia in systemic neuroimmune communication: functions beyond phagocytosis.Trends in immunology · 2026Review
- Varicella zoster virus and the central nervous system.Nature reviews. Microbiology · 2026Review
- Reply to Franzini et al. The Translational Medicine Regarding Ozone in Saline Solutions. Comment on "Armeli et al. Ozone Saline Solution Polarizes Microglial Cells Towards an Anti-Inflammatory Phenotype.Molecules (Basel, Switzerland) · 2026Article
- Translational evidence for increased central amygdala IL-6 activity in alcohol dependence.Journal of neuroinflammation · 2026Article
- Multiscale Approximations to Understand the Complex Role of Microglia in Alzheimer's Disease.The European journal of neuroscience · 2026Review
- Type-1 interferons associated with microglial-mediated neuroinflammation in Alzheimer's disease.Journal of neuroinflammation · 2026Review
- Dissecting microglial contributions to neurodegenerative disease pathophysiology using human pluripotent stem cells.Stem cell reports · 2026Review
- PLCG2 signaling and genetic resilience in Alzheimer's disease.Molecular neurodegeneration · 2026Review
- PU.1: the conductor of Alzheimer's symphony.Molecular neurodegeneration · 2026Article
- Genetic Architecture of Cognitive Resilience in Alzheimer's Disease: Mechanisms, Pathways, and Therapeutic Implications.Neurology international · 2026Review
- Cell type-resolved proteomics reveals intra- and intercellular signaling in Alzheimer's disease.bioRxiv : the preprint server for biology · 2026Article
- Single-cell transcriptomics reveals distinct microglial state remodeling associated with the (R)-nicotine/diosmetin combination and galantamine in LPS-challenged BV2 cells.Frontiers in immunology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
36 authors.
Pinar Ayata *Nash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. payata@gc.cuny.edu.ORCID 0000-0001-7621-832X
Jessica M Crowley *Nash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Matthew F Challman *Nash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Vinaya SahasrabuddheNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0003-0857-0326
Maud GratuzeDepartment of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.
Sebastian WerneburgDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Diogo RibeiroNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-6199-3120
Emma C HaysNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Violeta Durán-LaforetDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Travis E FaustDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.ORCID 0000-0002-4567-8435
Philip HwangNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francisco Mendes LopesMax Planck Institute for Biology of Ageing, Cologne, Germany.
Chrysa NikopoulouMax Planck Institute for Biology of Ageing, Cologne, Germany.
Sarah BuchholzMax Planck Institute for Biology of Ageing, Cologne, Germany.
Robert E MurphyDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
Taoyu MeiCologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0003-0865-9259
Anna A PimenovaNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Carmen Romero-MolinaNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Francesca GarrettiNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Tulsi A PatelNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Claudia De SanctisNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Angie V Ramirez JimenezBioinformatics for Next-Generation Sequencing (BiNGS) Core, Tisch Cancer Institute, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Megan CrowDepartment of Human Genetics, Genentech Inc., South San Francisco, CA, USA.
Felix D WeissInstitute of Innate Immunity, Department for Systems Immunology and Proteomics, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-0228-5081
Jason D UlrichDepartment of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-4743-926X
Edoardo MarcoraNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-3829-4927
John W MurrayColumbia Center for Human Development, Center for Stem Cell Therapies, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA.ORCID 0000-0002-4347-7824
Felix MeissnerInstitute of Innate Immunity, Department for Systems Immunology and Proteomics, Medical Faculty, University of Bonn, Bonn, Germany.ORCID 0000-0003-1000-7989
Andreas BeyerCologne Excellence Cluster for Aging and Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID 0000-0002-3891-2123
Dan HassonBioinformatics for Next-Generation Sequencing (BiNGS) Core, Tisch Cancer Institute, Department of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John F CraryNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-0556-293X
Dorothy P SchaferDepartment of Neurobiology, Brudnick Neuropsychiatric Research Institute, University of Massachusetts Chan Medical School, Worcester, MA, USA.
David M HoltzmanDepartment of Neurology, Hope Center for Neurological Disorders, Charles F. and Joanne Knight Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-3400-0856
Alison M GoateNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-0576-2472
Alexander TarakhovskyLaboratory of Immune Cell Epigenetics and Signaling, The Rockefeller University, New York, NY, USA.
Anne SchaeferNash Family Department of Neuroscience, Department of Psychiatry, Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. anne.schaefer@age.mpg.de.ORCID 0000-0002-1051-3710
Funding
Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4MProject 4 (Genetic modifiers for APOE-associated Alzheimer's disease pathogenesis)U19AG069701 · NIA · MAYO CLINIC JACKSONVILLE · PI Celeste Marie Karch · 2021 to 2026
$42.0MTHE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4MResearch Education ComponentP30AG066514 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Margaret Sewell · 2020 to 2026
$31.0MResearch Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI Susan Lynn Stark · 2020 to 2026
$28.7MVIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6MTranscription Factors in Stimulant and Opioid ActionP01DA047233 · NIDA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YASMIN L. HURD · 2019 to 2026
$16.5MDevelopment of PU.1 Inhibitory Modulators as Novel Therapeutics for Alzheimer's DiseaseU01AG066757 · NIA · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GOATE, ALISON M, RAY, WILLIAM J · 2020 to 2024
$8.0MEffect of APOE on CNS Neurons: Role of LRPRF1NS090934 · NINDS · WASHINGTON UNIVERSITY · PI HOLTZMAN, DAVID M. · 2020 to 2025
$6.5MNeuroprotective signaling and transcriptional pathways in microglia associated with Alzheimer's diseaseR01AG072489 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI ALISON M GOATE, Anne Schaefer · 2022 to 2026
$6.3MMicroglia-dependent mechanisms governing neural circuit plasticityR01MH113743 · NIMH · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Dorothy Patricia Schafer · 2017 to 2026
$4.9MGenomic approach to identification of microglial networks involved in Alzheimer’s disease riskU01AG058635 · NIA · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GOATE, ALISON M · 2018 to 2022
$4.8MMax Planck SocietyNCATS NIH HHS UL1 TR004419NCI NIH HHS P30 CA196521NEI NIH HHS P30 EY007003NIA NIH HHS F30 AG079491NIA NIH HHS F30 AG079492NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG066514NIA NIH HHS R01 AG068281NIA NIH HHS R01 AG068558NIA NIH HHS R01 AG072489NIA NIH HHS R01 AG085404NIA NIH HHS RF1 AG047644NIA NIH HHS RF1 AG054011NIA NIH HHS RF1 AG068281NIA NIH HHS RF1 AG068558NIA NIH HHS U01 AG058635NIA NIH HHS U01 AG066757NIA NIH HHS U19 AG069701NIDA NIH HHS P01 DA047233NIH HHS S10 OD026880NIH HHS S10 OD030463NIMH NIH HHS DP2 MH100012NIMH NIH HHS R01 MH113743NIMH NIH HHS R01 MH118329NINDS NIH HHS R01 NS106721NINDS NIH HHS R01 NS117533NINDS NIH HHS RF1 NS090934
Abstract
Microglia, the innate immune cells of the brain, play a defining role in the progression of Alzheimer's disease (AD)
Indexed as
Alzheimer DiseaseMicrogliaNeuroprotectionAnimalsCD28 AntigensDisease ProgressionFemaleHumansMaleMiceMice, Inbred C57BLPlaque, AmyloidProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-ActivatorsCD28 AntigensProto-Oncogene ProteinsProto-Oncogene Protein Spi-1Trans-Activators
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.