Evidence map›Paper›PMID 41193801›Full record

ArticleNature2025

A probabilistic histological atlas of the human brain for MRI segmentation.

Adrià Casamitjana, Matteo Mancini, Eleanor Robinson, Loïc Peter, Roberto Annunziata, Juri Althonayan, Shauna Crampsie, Emily Blackburn, Benjamin Billot, Alessia Atzeni and 14 more

Abstract read
In one paragraph

Article in Nature, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Review
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  5. Review
  6. Review
  7. Multiscale characterization of the human claustrum from histology to MRI.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Fast segmentation with the NextBrain histological atlas.bioRxiv : the preprint server for biology · 2025
    Article
  15. Article
  16. Article
  17. Fast segmentation with the NextBrain histological atlas.Imaging neuroscience (Cambridge, Mass.)
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

24 authors.

Adrià CasamitjanaDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Matteo ManciniDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Eleanor RobinsonDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Loïc PeterDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Roberto AnnunziataDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Juri AlthonayanDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Shauna CrampsieDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.ORCID 0000-0002-4399-5218
Emily BlackburnDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Benjamin BillotDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Alessia AtzeniDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Oula PuontiDanish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital - Amager and Hvidovre, Copenhagen, Denmark.ORCID 0000-0003-3186-244X
Yaël BalbastreDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK.
Peter SchmidtAdvanced Research Computing Centre, University College London, London, UK.
James HughesAdvanced Research Computing Centre, University College London, London, UK.ORCID 0000-0002-3022-3104
Jean C AugustinackAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Brian L EdlowAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0001-7235-8456
Lilla ZölleiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.ORCID 0000-0002-6447-9626
David L ThomasDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0003-1491-1641
Dorit KliemannDepartment of Psychological and Brain Sciences, The University of Iowa, Iowa City, IA, USA.
Martina BocchettaDementia Research Centre, Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0003-1814-5024
Catherine StrandQueen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Janice L HoltonQueen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
Zane JaunmuktaneQueen Square Brain Bank for Neurological Disorders, Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.ORCID 0000-0001-7738-8881
Juan Eugenio IglesiasDepartment of Medical Physics and Biomedical Engineering, University College London, London, UK. jiglesiasgonzalez@mgh.harvard.edu.ORCID 0000-0001-7569-173X

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
Functionally guided adult whole brain cell atlas in human and NHPUM1MH130981 · NIMH · ALLEN INSTITUTE · PI Ed Lein, Hongkui Zeng · 2022 to 2026
$91.9M
Acquisition-independent machine learning for morphometric analysis of underrepresented aging populations with clinical and low-field brain MRIRF1AG080371 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Juan Eugenio Iglesias Gonzalez · 2023 to 2026
$4.0M
Diagnosing the undiagnosable: studies of Alzheimer disease mimics and confounders via "neuropathometry" of dissection photos with 3D scanningR01AG070988 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI IGLESIAS GONZALEZ, JUAN EUGENIO · 2021 to 2025
$2.7M
Open-source software for multi-scale mapping of the human brainRF1MH123195 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI FISCHL, BRUCE, IGLESIAS GONZALEZ, JUAN EUGENIO · 2020 to 2020
$2.0M
Brainstem Connectome Mapping to Guide Targeted Stimulant Therapy in Patients with Traumatic ComaR21NS109627 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI EDLOW, BRIAN L. · 2019 to 2020
$480k
NIA NIH HHS R01 AG070988NIA NIH HHS RF1 AG080371NIA NIH HHS U01 AG024904NIMH NIH HHS RF1 MH123195NIMH NIH HHS UM1 MH130981NINDS NIH HHS R21 NS109627Wellcome Trust
6 · The paper itself

Abstract

In human neuroimaging, brain atlases are essential for segmenting regions of interest (ROIs) and comparing subjects in a common coordinate frame. State-of-the-art atlases derived from histology

Indexed as

Atlases as TopicBrainMagnetic Resonance ImagingNeuroimagingAlzheimer DiseaseArtificial IntelligenceBayes TheoremFemaleHumansImaging, Three-DimensionalMaleProbability

Identifiers

PMID41193801
PMCPMC12711564

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.