ArticleCurrent genetics2025
Genomic surveillance of vancomycin-resistant Enterococcus faecium: a study on Resistome, Plasmidome, and mobilome profiling.
Article in Current genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Clade-specific evolution and genome plasticity underlying antimicrobial resistance in Enterococcus faecium.Archives of microbiology · 2026Review
- Identification of essential genes for conjugative transfer in antimicrobial resistance-associated pELF-type linear plasmids of opportunistic pathogen Enterococcus faecium.PLoS pathogens · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Vancomycin-resistant enterococci (VRE) are critical nosocomial pathogens, classified as high priority by the World Health Organization (WHO) due to rising antibiotic resistance. Among these, Vancomycin-resistant Enterococcus faecium (VREfm) presents a significant clinical challenge, frequently detected in healthcare-associated infections and exhibiting resistance to multiple antibiotics. This study presents a genomic surveillance analysis of 63 Enterococcus faecium (E. faecium) isolates obtained from the public database from India during the period January 2017 to December 2021. These isolates were confirmed as VREfm, making them valuable for understanding the key resistance genes and mutations commonly associated with strains. Genomic analysis revealed diverse plasmid replicons such as pRE25, pRUM, and pIP501, often coexisting in single isolates, indicating active horizontal gene transfer. Multiple antimicrobial resistance genes, such as vanHAX, ermB, optrA, and blaOXA-232, were identified along with insertion sequences (IS3, ISL3, IS256), integrons, and transposons (Tn1546, Tn917). Mutations in GyrA, ParC, and PBP5 proteins associated with fluoroquinolone and β-lactam antibiotics were also detected in each isolate. Amino acid substitutions associated with daptomycin resistance were identified in the encoded proteins of the liaR (LiaR-W73C), liaS (LiaS-T120A), cls (Cls-T298S), and rpoB (RpoB-S491F) genes. Three novel deleterious amino acid substitutions were also observed in Cls-R424S, RpoB-M475V, and RpoC-T634K, encoded by the cls, rpoB, and rpoC genes, respectively, that may impact protein function. Overall, this genomic survey provides a framework for hypothesis-driven studies exploring resistance evolution and gene mobility in E. faecium.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.