Evidence map›Paper›PMID 41193704›Full record

ArticleHypertension research : official journal of the Japanese Society of Hypertension2026

Visit-to-visit blood pressure variability, brain MRI measures, and cognition in non-demented older adults.

Jiangbo Cui, Caroline Robert, An Qi Toh, Eddie J Y Chong, Joyce R Chong, Yuan Cai, Narayanaswamy Venketasubramanian, Mitchell K P Lai, Saima Hilal, Christopher Chen

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Article in Hypertension research : official journal of the Japanese Society of Hypertension, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Jiangbo CuiDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Caroline RobertDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
An Qi TohDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Eddie J Y ChongDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Joyce R ChongDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Yuan CaiDivision of Neurology, Department of Medicine and Therapeutics, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong SAR, China.
Narayanaswamy VenketasubramanianRaffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore.
Mitchell K P LaiDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Saima HilalDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Christopher ChenDepartment of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. phccclh@nus.edu.sg.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Blood pressure variability (BPV) may be a potentially modifiable risk factor for dementia. However, longitudinal studies investigating the associations between BPV, cerebrovascular disease (CeVD), and brain atrophy remain limited. Importantly, it is unclear whether these brain structural changes mediate the relationship between BPV and cognition, and whether such mediation effects are independent of preexisting brain pathology. This study included 362 non-demented individuals who underwent at least two neuropsychological assessments or brain magnetic resonance imaging (MRI). BPV was calculated as variation independent of mean. MRI markers of CeVD (i.e., white matter hyperintensity [WMH], lacunes, cerebral microbleeds [CMBs], intracranial stenosis, and cortical infarcts) and brain atrophy (i.e., white matter volume [WMV], gray matter volume [GMV], and lateral ventricular volume [VV]), were evaluated. Plasma p-tau181 was measured as a marker of amyloid pathology. Higher systolic BPV (SBPV) was associated with worse cognitive outcomes. SBPV was associated with WMH, cortical infarcts, and VV at the final brain MRI. These results were consistent in longitudinal analyses. The association between SBPV and cognition was partially mediated by CeVD and brain atrophy, with mediation proportion ranging from 17 to 24% for CeVD and 14 to 35% for brain atrophy. Preexisting CeVD and amyloid pathology had minimal influence on these mediation effects. SBPV showed stronger effects than other BPV indices on cognition, CeVD, and brain atrophy.

Indexed as

Blood PressureBrainCognitionAgedAged, 80 and overAtrophyCerebrovascular DisordersFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedNeuropsychological TestsBlood pressure variabilityBrain atrophyCerebrovascular diseaseCognition

Identifiers

PMID41193704

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.