SynthesisJournal of perinatology : official journal of the California Perinatal Association2025
Effect of glucose on pain relief during invasive procedures in premature infants: Systematic review and meta-analysis of randomized controlled trials.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
This meta-analysis aimed to evaluate the effectiveness and safety of the minimally effective dose and optimal concentration of oral glucose for pain relief during painful procedures. Systematic review and meta-analysis were conducted following PRISMA guidelines. Protocol was registered with PROSPERO (CRD42021236217). PubMed, Cochrane, Embase, Web of Science, and Scopus were searched until September 2024. Continuous data were analyzed using inverse-variance fixed effects analysis. Risk of bias and GRADE assessment were performed using RoB 2.0 and GRADEpro tools. Sixteen RCTs with 500 preterm infants were included. Meta-analysis revealed that 25% glucose significantly reduced pain compared to breast milk during heel lance at 30 s. No significant differences in heart rate (HR) or oxygen saturation (SpO₂) were observed between glucose and breast milk. However, 25% glucose significantly reduced HR and improved SpO₂ levels compared to placebo. Oral glucose is an effective, safe pain management strategy in neonatal care. A meta-analysis showing that 25% oral glucose significantly reduced pain versus breast milk during heel lance, and improved heart rate and oxygen saturation compared with placebo. Oral glucose is a safe, effective strategy for neonatal pain management. Created in https://BioRender.com (accessed on 11 February 2025).
Indexed as
Identifiers
41193647What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.