ArticleScientific reports2025
miRNA-1175 downregulates a long non-coding natural antisense RNA and promotes long term memory.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Single-trial induced long-term memories (LTMs) require fast removal of inhibitory memory constraints following learning. We propose that the interplay between short non-coding RNAs (sncRNAs) and long non-coding RNAs (lncRNAs) is engaged in this process, suggesting the existence of a new and unexpected pathway for LTM formation. In the mollusc Lymnaea, this pathway involves the functional interaction between a typical sncRNA, Lym-miR-1175, and a lncRNA, Lym-NOS1AS. In the current study, we validate this hypothesis and provide evidence that: (1) LTM formation in Lymnaea is associated with the timed and targeted changes in the expression of Lym-miR-1175; (2) Lym-miR-1175 is a negative regulator of the Lym-NOS1AS; (3) Lym-miR-1175 is required for single-trial induced LTM; (4) Lym-miR-1175 and Lym-NOS1AS are co-expressed in a key neuron of the Lymnaea memory network. Thus, our data indicate an important role of the interaction between a miRNA and a lncRNA in one-trial learning.
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