Evidence map›Paper›PMID 41193620›Full record

ArticleScientific reports2025

Hydrogel nanocomposite-based breathable non-adhesive coating for oxygen sensing film used within extracorporeal perfusion system.

Badri Parshad, Xingyu Hu, Isabelle Nagle, Shatruhan Singh Rajput, Fei Peng, Emmanouil Roussakis, Juan Pedro Cascales, Tyler McPartland, Anna Wiatrowski, Julia Byrne Slade and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Sprayable Hydrogel Dressings in Wound-Healing Applications.Bioengineering (Basel, Switzerland) · 2026
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Badri Parshad *Wellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Xingyu Hu *Departments of Chemistry and Biomedical Engineering, Boston University, Boston, 02215, USA.
Isabelle NagleWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Shatruhan Singh RajputDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.
Fei PengWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Emmanouil RoussakisWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Juan Pedro CascalesWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Tyler McPartlandWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Anna WiatrowskiWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Julia Byrne SladeWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA.
Trong NguyenDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.
Rachel S KnipeDivision of Pulmonary and Critical Care Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02129, USA.
Mark W GrinstaffDepartments of Chemistry and Biomedical Engineering, Boston University, Boston, 02215, USA.
Conor L EvansWellman Center for Photomedicine, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA, 02129, USA. Evans.Conor@mgh.harvard.edu.

Funding

Air Force Office of Scientific Research FA9550-20-1-0063Northeastern Section, American Chemical Society Norris-Richards Summer Research Scholarship
6 · The paper itself

Abstract

Real-time, quantitative biosensing within extracorporeal perfusion (ECP) and extracorporeal membrane oxygenation (ECMO) systems is key to advancing this life-support technology beyond the hospital setting to emergency care. Measuring and monitoring [Formula: see text] concentration in blood is particularly important but is challenged by fouling of the sensor. Here we report a novel hydrogel nanocomposite coating, composed of polysulfobetaine, polyethylene glycol, and titanium dioxide nanoparticles, for a metalloporphyrin-based oxygen sensor. The hydrogel nanocomposite exhibits minimal cytotoxicity and hemolytic effects (< 5%), as well as non-adhesive and non-coagulant properties in contact with lung endothelial cells and human plasma, ensuring its compatibility with blood-contacting applications. The incorporation of titanium dioxide nanoparticles provides a white, light-scattering surface to improve sensor signal reflection, enhances the hydrogel's mechanical strength (storage modulus > 1000 Pa), and maintains a pore area on the order of μm

Indexed as

Biosensing TechniquesCoated Materials, BiocompatibleExtracorporeal Membrane OxygenationHydrogelsNanocompositesOxygenHumansPolyethylene GlycolsTitaniumCoated Materials, BiocompatibleHydrogelsOxygenPolyethylene GlycolsTitaniumtitanium dioxide

Identifiers

PMID41193620
PMCPMC12589492

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.