Prenatal methamphetamine exposure induces oxidative stress and apoptosis in the ovaries of rat offspring.

Mozhdeh Ebrahimi, Nayere Zare, Batool Ghorbani Yekta

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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

3 authors.

Mozhdeh EbrahimiDepartment of Developmental Biology, Faculty of Advanced Sciences and Technology, TeMS.C. Islamic Azad University, Tehran, Iran.

Nayere ZareDepartment of Anatomical Sciences and Cognitive Neuroscience, Faculty of Medicine, TeMS.C. Islamic Azad University, Tehran, Iran.

Batool Ghorbani YektaDepartment of Physiology, Faculty of Medical Sciences, TeMS.C. Islamic Azad University, Tehran, Iran. bahareh59gh@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methamphetamine abuse among women of reproductive age is a growing concern, necessitating investigation of its intrauterine effects on offspring. In this study, we examined the induction of oxidative stress and apoptosis in the ovaries of rat offspring following maternal methamphetamine exposure. Pregnant Wistar rats received methamphetamine (2 mg/kg or 5 mg/kg) from gestational day 10 until delivery. Control rats received 0.9% saline (1 mL/kg) on the same schedule. Female offspring were raised to puberty and their ovaries were examined, compared to controls. Protein expression levels of FASL and TRAIL were assessed by immunohistochemistry, and antioxidant enzyme levels (superoxide dismutase, SOD) and oxidative stress marker levels (malondialdehyde, MDA) were evaluated by ELISA

Indexed as

ApoptosisMethamphetamineOvaryOxidative StressPrenatal Exposure Delayed EffectsAnimalsFas Ligand ProteinFemaleMalondialdehydePregnancyRatsRats, WistarSuperoxide DismutaseFas Ligand ProteinMalondialdehydeMethamphetamineSuperoxide DismutaseFASL protein expressionIntrauterine methamphetamine exposureMalondialdehyde (MDA)Rat modelSuperoxide dismutase (SOD)TRAIL protein expression

Identifiers

PMID41193606

DOI10.1038/s41598-025-22487-0

PMCPMC12589608

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.