ArticleJournal of the American Chemical Society2025
Metallo-coiled Coil Stabilization via Chemical Cross-Linking: Implications for Gd(III)-Based MRI Contrast Agents.
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- A Modular Core-Shell Nanoparticle Platform for Dual-Modal MRI-Luminescence With High Relaxivity.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Recent Advances in Lanthanide Complexes in Biological Systems: Coordination Principles and Interactions with Biomolecules.International journal of molecular sciences · 2026Review
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Authors and funding
11 authors.
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Abstract
Coiled coils are a versatile class of protein-inspired metal-binding ligands with well-defined sequence-to-structure relationships and high synthetic accessibility, making them promising tunable ligands for applications spanning biomedical imaging, catalysis, and material science. However, their practical utility is often limited by poor stability, particularly under physiological conditions. Herein, we introduce a covalent interhelical isopeptide cross-linking strategy that significantly enhances the thermal, thermodynamic, kinetic, and proteolytic stability of lanthanide-bound coiled coils designed for use as MRI contrast agents. Biophysical analysis, including CD, native MS, HPLC, and fluorescence assays, reveal that introduction of a single cross-linking layer promotes structural organization, driving the peptide from an unfolded to a well-folded state. Cross-linking leads to a remarkable 2.5 × 10
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