Trial reportThe American journal of clinical nutrition2025
Egg supplementation for 24 weeks does not improve linear growth or reduce small intestinal permeability in Sierra Leonean children with moderate wasting: a randomized, blinded, controlled trial.
Trial report in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06002438 (Egg to Ameliorate Environmental Enteric Dysfunction and Improve Growth in Children With Moderate Acute Malnutrition), which is not on this map. Not yet cited in PubMed.
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Egg to Ameliorate Environmental Enteric Dysfunction and Improve Growth in Children With Moderate Acute Malnutrition
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12 authors.
Funding
Abstract
backgroundEnvironmental enteric dysfunction and linear growth faltering are common among children with moderate acute malnutrition (MAM) in low-income countries. Eggs contain high-quality protein and bioactive compounds that may improve gut integrity and growth.
objectivesThis study aims to determine if daily supplementation with whole egg powder compared with corn flour for 24 wk reduces small intestinal permeability and improves linear growth in children with MAM.
methodsThis individually randomized, outcomes-assessor and investigator-blinded, controlled trial enrolled participants aged 6-30 mo with MAM in Pujehun District, Sierra Leone. Participants received either 15 g/d whole egg powder or nearly isoenergetic corn flour for 24 wk. All children received Supercereal Plus for 6 wk, daily micronutrient supplementation, and malaria chemoprophylaxis every 6 wk. Primary outcomes were change in length-for-age z-score (ΔLAZ) at 12 and 24 wk and percent urinary lactulose excretion (%L) at 12 and 24 wk.
resultsOf 461 enrolled children, 338 (73%) were eligible for ≥1 primary outcome analysis at 12 wk and 272 (59%) at 24 wk. No differences were observed in ΔLAZ at 12 wk [difference = 0.01; 95% confidence interval (CI): -0.09, 0.11; P = 0.79] or 24 wk (difference = 0.08; 95% CI: -0.05, 0.21; P = 0.22). Over 90% of participants had increased intestinal permeability, and there were no differences in %L excretion at 12 wk (median of differences: 0.02; 95% CI: -0.03, 0.07; P = 0.44) or 24 wk (median of differences = 0.0; 95% CI: -0.05, 0.06; P = 0.90). No significant differences were observed in the rates of weight, length, or mid-upper arm circumference gain.
conclusionsSupplementation with whole egg powder for 24 wk, while providing ample amounts of essential amino acids, did not improve linear growth or reduce small intestinal permeability when compared with corn flour in children with MAM. This trial was registered at clinicaltrials.gov as NCT06002438.
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