Evidence map›Paper›PMID 41193032›Full record

ArticleThe American journal of clinical nutrition2025

High concentrations of polyunsaturated n-3 fatty acids in serum are inversely associated with risk of future incident venous thromboembolism - the HUNT cohort study.

Magdalena Johansson, Sigrid K Brækkan, Guro F Giskeødegård, Kaitlin H Wade, Kristian D Hindberg, Nicholas Timpson, George Davey Smith, Kristian Hveem, Bjørn Olav Åsvold, Ben M Brumpton and 1 more

Abstract read
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In one paragraph

Article in The American journal of clinical nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. SerumFrontiers in nutrition · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Magdalena JohanssonSkellefteå Research Unit, Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden; Thrombosis Research Group (TREC), Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway. Electronic address: magdalena.johansson@umu.se.
Sigrid K BrækkanThrombosis Research Group (TREC), Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway; Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Guro F GiskeødegårdDepartment of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Surgery, St. Olav's University Hospital, Trondheim, Norway.
Kaitlin H WadeMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Kristian D HindbergThrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.
Nicholas TimpsonMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
George Davey SmithMRC Integrative Epidemiology Unit (IEU), Bristol Medical School, University of Bristol, Bristol, UK.
Kristian HveemHUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway; HUNT Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Levanger, Norway.
Bjørn Olav ÅsvoldHUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; HUNT Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Levanger, Norway; Department of Endocrinology, Clinic of Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
Ben M BrumptonHUNT Center for Molecular and Clinical Epidemiology, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; HUNT Research Center, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Levanger, Norway; Clinic of Medicine, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
John-Bjarne HansenThrombosis Research Group (TREC), Department of Clinical Medicine, UiT - The Arctic University of Norway, Tromsø, Norway; Thrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrevious studies on the association between n-3 (ω-3) polyunsaturated fatty acids (n-3 PUFAs) and risk of venous thromboembolism (VTE), mainly derived from self-reported dietary intake of n-3 PUFAs, have shown mixed results.

objectivesThe aim of this cohort study was to investigate the association between measured serum n-3 PUFA concentrations and risk of first-ever VTE.

methodsThe present cohort (N = 17,087) was derived from the third survey of the Trøndelag Health Study and consisted of individuals aged ≥20 y without previous VTE. Serum n-3 PUFA concentrations were measured in blood drawn at inclusion (2006-2008) using a nuclear magnetic resonance metabolomic platform (Nightingale), and participants were followed until an objectively verified first-ever VTE event, death, migration, or 31 December, 2019. Cox regression was used to estimate hazard ratios (HRs) with 95% confidence intervals (CIs).

resultsDuring a median follow-up of 12 y, 340 experienced an incident VTE event. Participants with n-3 PUFA concentrations in the highest tertile had 28% lower relative risk of VTE (HR: 0.72; 95% CI: 0.54, 0.96) than those with n-3 PUFAs in the lowest tertile in age-adjusted analysis. The inverse association was most pronounced for provoked VTE (HR: 0.62; 95% CI: 0.44, 0.87) and deep vein thrombosis (HR: 0.61; 95% CI: 0.40, 0.93). HRs remained virtually unaffected after further adjustment for sex, body mass index, and history of cardiovascular disease or cancer at baseline.

conclusionsOur finding of an inverse association between serum n-3 PUFA concentrations and VTE suggest that a diet enriched with n-3 PUFAs might protect against future VTE.

Indexed as

Fatty Acids, Omega-3Venous ThromboembolismAdultAgedCohort StudiesFemaleHumansIncidenceMaleMiddle AgedNorwayRisk FactorsFatty Acids, Omega-3cohort studiesdeep vein thrombosislipidsomega-3 fatty acidsprospective studiespulmonary embolismrisk factorvenous thromboembolismvenous thrombosis

Identifiers

PMID41193032
PMCPMC12799366

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.