Evidence map›Paper›PMID 41192952›Full record

Trial reportPsycho-oncology2025

Chemotherapy Under Fire: Narratives of Patients With Cancer During Wartime.

Eran Ben-Arye, Orit Gressel, Yael Keshet, Jan Vagedes, Noah Samuels, Vika Schachter, Galit Galil, Meirav Schmidt, Sameer Kassem

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psycho-oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Eran Ben-AryeRuth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-4058-3672
Orit GresselRuth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Yael KeshetDepartment of Sociology, Western Galilee Academic College, Acre, Israel.
Jan VagedesARCIM Institute, Research Institute, Filderstadt, Germany.ORCID 0000-0002-0021-088X
Noah SamuelsFaculty of Medicine, Center for Integrative Complementary Medicine, Shaare Zedek Medical Center, Hebrew University of Jerusalem, Jerusalem, Israel.
Vika SchachterRuth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
Galit GalilIntegrative Oncology Program, The Oncology Service; Lin, Carmel, and Zebulun Medical Centers, Clalit Health Services, Haifa, Israel.
Meirav SchmidtUnit of Gynecologic Oncology, Department of Obstetrics and Gynecology, Carmel Medical Center, Haifa, Israel.
Sameer KassemRuth and Bruch Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.

Funding

Israel Cancer Association 18042024
6 · The paper itself

Abstract

STUDY

objectivePatients with cancer living in regions of war face significant quality of life (QoL)-related concerns, both cancer- and war-related. This study examined the correlation between narratives of patients referred to an integrative oncology (IO) program in northern Israel and heart rate variability (HRV) measurements.

methodsThe study was nested within an ongoing prospective, randomized controlled trial, assessing IO interventions on QoL-related concerns among patients with cancer undergoing chemotherapy. Patients reporting cancer- and war-related concerns were eligible for study inclusion. Narratives from two open-ended questions addressing personal and health-related effects of the war were analyzed qualitatively using ATLAS.Ti software for systematic coding; and baseline electrocardiogram conducted for HRV measurement.

resultsAnalysis of 125 patient narratives identified many war-related experiences and emotions, most significantly stress, fear, anxiety, distress, sadness, loneliness, and reduced daily functioning. In 36 patients (28.8%), a significant association was found between war and cancer-related concerns (e.g., pain, appetite, gastro-intestinal and emotional distress, insomnia). HRV analysis suggested a correlation between expressing both cancer- and war-related concerns with higher Power high-frequency (HF) [correlation: 0.24 (0.01, 0.44), p = 0.039]; Power lower frequency (LF) [correlation: 0.27 (0.06, 0.47), p = 0.015]; and autocorrelation slope [0.25 (0.05, 0.44); p = 0.015].

conclusionsPatients with cancer- and war-related concerns reported a significant impact of the war on health, especially QoL cancer-related concerns. Baseline HRV analysis suggests that those expressing both groups of concerns showed increased sympathetic and para-sympathetic activity. Further research is needed to examine the impact of war on cancer care.

Indexed as

NeoplasmsQuality of LifeWarfareAdultAgedAnxietyFemaleHeart RateHumansIsraelMaleMiddle AgedNarrationProspective StudiesStress, Psychologicalanxietycancerheart rate variabilityintegrative medicineintegrative oncologypalliative carewar

Identifiers

PMID41192952
PMCPMC12588825

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.