Evidence map›Paper›PMID 41192945›Full record

ArticleThe British journal of ophthalmology2026

Retinal nerve fibre layer optical texture analysis: retinal nerve fibre bundle defect patterns and the extent of macular involvement across different stages of glaucoma.

Alireza Kamalipour, Sasan Moghimi, Pooya Khosravi, Natchada Tansuebchueasai, Andrew Steven Camp, Cristiana Vasile, Mohsen Adelpour, Gopikasree Gunasegaran, Michael Saheb Kashaf, Takashi Nishida and 4 more

Abstract read
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In one paragraph

Article in The British journal of ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alireza KamalipourViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0003-2916-9187
Sasan MoghimiViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-9375-4711
Pooya KhosraviViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-3631-4760
Natchada TansuebchueasaiOphthalmology, Prince of Songkla University, Hat Yai, Songkhla, Thailand.ORCID http://orcid.org/0000-0003-4776-9610
Andrew Steven CampOphthalmology, University of California at San Diego Department of Ophthalmology at the Shiley Eye Institute, San Diego, California, USA.ORCID http://orcid.org/0000-0001-5954-5257
Cristiana VasileViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Mohsen AdelpourViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Gopikasree GunasegaranViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Michael Saheb KashafViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.
Takashi NishidaViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-8312-6623
Linda M ZangwillViterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California, USA.ORCID http://orcid.org/0000-0002-1143-5224
Alexander K N LamDepartment of Ophthalmology, The University of Hong Kong, Hong Kong, Hong Kong.
Christopher Kai-Shun LeungOphthalmology, The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, Hong Kong.
Robert N WeinrebHamilton Glaucoma Center, Shiley Eye Institute and Department of Ophthalmology, University of California San Diego, La Jolla, California, USA rweinreb@ucsd.edu.ORCID http://orcid.org/0000-0001-9553-3202

Funding

African Descent And Glaucoma Evaluation Study (ADAGES)U10EY014267 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2002 to 2010
$13.2M
Vision BiostatisticsP30EY022589 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2012 to 2026
$10.3M
Diagnostic Innovations in Glaucoma:Structural AssessmentR01EY011008 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 1995 to 2015
$8.7M
Diagnostic Innovations in Glaucoma Study (DIGS): High Myopia and Advanced DiseaseR01EY027510 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LINDA M ZANGWILL · 2017 to 2026
$5.3M
Diagnosis and Monitoring of Glaucoma with Optical Coherence Tomography AngiographyR01EY029058 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI WEINREB, ROBERT N · 2018 to 2024
$4.2M
African Descent and Glaucoma Evaluation (ADAGES) II: Glaucoma ProgressionR01EY019869 · NEI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ZANGWILL, LINDA M · 2010 to 2014
$2.8M
African Descent and Glaucoma Evaluation (ADAGES) IV: Alterations of the lamina cribrosa in progressionR01EY026574 · NEI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FAZIO, MASSIMO ANTONIO, GIRKIN, CHRISTOPHER ANTHONY · 2017 to 2020
$2.6M
Deep Learning-based retinal optical coherence tomography markers for optic neuropathiesF30EY036725 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI Pooya Khosravi · 2024 to 2026
$136k
NEI NIH HHS F30 EY036725NEI NIH HHS P30 EY022589NEI NIH HHS R01 EY011008NEI NIH HHS R01 EY019869NEI NIH HHS R01 EY026574NEI NIH HHS R01 EY027510NEI NIH HHS R01 EY029058NEI NIH HHS U10 EY014267
6 · The paper itself

Abstract

BACKGROUND/

aimsTo apply retinal nerve fibre layer (RNFL) optical texture analysis (ROTA) to investigate (1) the patterns of RNFL bundle defects, and (2) the frequency of papillomacular and papillofoveal bundle involvement across early, moderate and advanced glaucoma.

methodsAll eyes underwent 24-2 visual field (VF) testing and optical coherence tomography (OCT) for ROTA. The borders of RNFL defects were delineated from ROTA, and the involvement of the arcuate, papillomacular and papillofoveal bundles was determined for each eye. 24-2 VF stimulus projections were mapped onto the corresponding topographic areas of ROTA images. Multilevel logistic regression analysis was applied to evaluate the structure-function association.

resultsPapillomacular bundle defects were highly prevalent in glaucoma, increasing from 87.7% in early to 95.35% in moderate and 100% in advanced glaucoma. Papillofoveal bundle defects were also common, increasing from 29.7% in early to 36.05% in moderate and 60.98% in advanced glaucoma. Central four 24-2 test locations that projected onto the trajectories of papillomacular or papillofoveal RNFL bundle defects demonstrated significantly increased likelihood of VF sensitivity abnormality (ORs of 22.42 at PDP<5% and 20.26 at TDP<5%, respectively, p<0.001 for both).

conclusionROTA uncovers a wide spectrum of RNFL bundle defects spanning the entire glaucoma continuum. It also provides visualisation of the preserved RNFL bundles in advanced glaucoma. Papillomacular and papillofoveal RNFL bundle defects are present in a considerable proportion of eyes with early, moderate and advanced glaucoma, and, when detected, they significantly increase the likelihood of abnormality in the corresponding central 24-2 test locations.

Indexed as

GlaucomaMacula LuteaNerve FibersOptic DiskOptic Nerve DiseasesRetinal Ganglion CellsAgedFemaleHumansIntraocular PressureMaleMiddle AgedTomography, Optical CoherenceVisual FieldsVisual Field TestsGlaucoma

Identifiers

PMID41192945
PMCPMC12747123

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.