ArticleInternal medicine (Tokyo, Japan)2026
Successful Rechallenge of Trastuzumab Deruxtecan Following Early Detection of ILD in a Patient with Non-small Cell Lung Carcinoma Harboring HER2 Exon 20 Insertion.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Long term survival with trastuzumab deruxtecan for heavily pretreated, HER2 mutated advanced non-small cell lung cancer.Discover oncology · 2026Article
- HER2-mutated lung squamous cell carcinoma responding to trastuzumab deruxtecan followed by pyrotinib: a Case Report.Frontiers in pharmacology · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
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Abstract
We herein report the case of a 78-year-old woman with non-small cell lung carcinoma (NSCLC) harboring a HER2 exon 20 insertion, who developed grade 1 trastuzumab deruxtecan (T-DXd)-induced interstitial lung disease (ILD) during third-line therapy. Oral corticosteroid administration led to radiological improvement, enabling T-DXd re-administration at a reduced dose. She received eight additional cycles (nine in total), resulting in tumor regression without ILD recurrence. Given that T-DXd is currently the only approved HER2-targeted therapy for NSCLC in our country, this case underscores the importance of early detection and appropriate management of ILD to maximize the therapeutic benefits.
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