ArticleInternal medicine (Tokyo, Japan)2026
Recurrent IgA1-λ-Type PGNMID Achieving Remission with Conventional Immunosuppressive Therapy.
Article in Internal medicine (Tokyo, Japan), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A 58-year-old man was admitted to our hospital in April 2013 with elevated serum creatinine levels, proteinuria, and hematuria. A renal biopsy revealed membranoproliferative glomerulonephritis-like changes. Immunofluorescence showed IgA1 and λ light chain deposits along the capillary walls, confirming IgA-λ type proliferative glomerulonephritis with monoclonal immunoglobulin deposits (PGNMID). Complete remission was achieved with glucocorticoid monotherapy in December 2013. After a relapse in April 2021, immunosuppressive treatment, including intravenous cyclophosphamide and subsequent mycophenolate mofetil, led to a complete remission. This case indicates that conventional immunosuppressive therapy may be effective for IgA-type PGNMID.
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