Evidence map›Paper›PMID 41192405›Full record

ArticleNeurobiology of aging2026

Hippocampal 1H-MR spectroscopy metabolites are linked to CSF tau pathology in cognitively unimpaired older adults along the Alzheimer's continuum.

Jessica N Lingad, Casey R Vanderlip, Sierra Wright, Lorena Sordo, Elizabeth Head, Craig E L Stark

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of aging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Digital cognitive phenotyping enhances risk stratification in preclinical Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Jessica N LingadUniversity of California, Irvine, School of Biological Sciences, Department of Neurobiology and Behavior, 1400 Biological Sciences III, Irvine, CA 92697, United States. Electronic address: nochej@uci.edu.
Casey R VanderlipUniversity of California, Irvine, School of Biological Sciences, Department of Neurobiology and Behavior, 1400 Biological Sciences III, Irvine, CA 92697, United States. Electronic address: vanderlc@uci.edu.
Sierra WrightUniversity of California, Irvine, School of Medicine, Department of Pathology & Laboratory Medicine, Gillespie Neuroscience Research Facility, 837 Health Sciences Rd, Irvine, CA 92697-4540, United States. Electronic address: stwright@uci.edu.
Lorena SordoUniversity of California, Irvine, School of Medicine, Department of Pathology & Laboratory Medicine, Gillespie Neuroscience Research Facility, 837 Health Sciences Rd, Irvine, CA 92697-4540, United States. Electronic address: sordolorena@gmail.com.
Elizabeth HeadUniversity of California, Irvine, School of Medicine, Department of Pathology & Laboratory Medicine, Gillespie Neuroscience Research Facility, 837 Health Sciences Rd, Irvine, CA 92697-4540, United States; University of California, Irvine, School of Medicine, Department of Neurology, Gillespie Neuroscience Research Facility, 837 Health Sciences Rd, Irvine, CA 92697-4540, United States. Electronic address: heade@uci.edu.
Craig E L StarkUniversity of California, Irvine, School of Biological Sciences, Department of Neurobiology and Behavior, 1400 Biological Sciences III, Irvine, CA 92697, United States. Electronic address: cestark@uci.edu.

Funding

The Alzheimer's Disease Research Center at the University of California, IrvineP30AG066519 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Crystal M. Glover · 2020 to 2026
$27.9M
Using MR Spectroscopy to Measure Mammalian Neurogenesis in VivoR01AG076942 · NIA · BAYLOR COLLEGE OF MEDICINE · PI MIRJANA MALETIC-SAVATIC, Craig E Stark · 2022 to 2026
$3.8M
Training in Translational ADRD Neuroscience (TITAN)T32AG073088 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2021 to 2026
$2.2M
Summer Medical student Aging and Alzheimer disease Research Training (SMAART) programT35AG076424 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI Joshua Grill, Elizabeth Head · 2022 to 2026
$361k
NIA NIH HHS P30 AG066519NIA NIH HHS R01 AG076942NIA NIH HHS T32 AG073088NIA NIH HHS T35 AG076424
6 · The paper itself

Abstract

Relationships between Alzheimer's disease (AD) pathologies in cognitively unimpaired adults and in vivo neurometabolic properties measured directly from the hippocampus, a vulnerable region early along the AD continuum, are not well-understood in the earliest stages of AD. In a 3T

Indexed as

AgingAlzheimer DiseaseCognitionHippocampusProton Magnetic Resonance Spectroscopytau ProteinsAgedAged, 80 and overAmyloid beta-PeptidesAspartic AcidBiomarkersCholineCreatineFemaleHumansInositolAmyloid beta-PeptidesAspartic AcidBiomarkersCholineCreatineInositolN-acetylaspartatetau ProteinsAgingAlzheimer’s diseaseBiomarkersCerebrospinal fluid, magnetic resonance imaging, hippocampusMagnetic resonance spectroscopyNeuroinflammationNeurometabolism

Identifiers

PMID41192405
PMCPMC13379048

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.