Oleoyl coenzyme A triggers peroxygenase activity in cytochrome c.

Patrick A Kates, Sofía E Gómez, John T Groves

Abstract read

In one paragraph

Article in Journal of inorganic biochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Patrick A KatesDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

Sofía E GómezDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States.

John T GrovesDepartment of Chemistry, Princeton University, Princeton, New Jersey 08544, United States. Electronic address: jtgroves@princeton.edu.

Funding

Molecular Probes of the Mechanisms of Cytocrhome P450R37GM036298 · NIGMS · PRINCETON UNIVERSITY · PI GROVES, JOHN TAYLOR · 2007 to 2016

$3.7M

NIGMS NIH HHS R37 GM036298

6 · The paper itself

Abstract

The oxidation of cardiolipin by cytochrome c (cyt c) plays a crucial role in cyt c release from mitochondria at the initiation of apoptosis. Herein we report the first evidence of cytochrome c acting as a peroxygenase in the presence of cardiolipin-mimics. The interaction of cyt c and oleoyl-CoA in the presence of primary amines results in conformational change, hydrogen peroxide-mediated substrate oxidation, acyl transfer to form N-acyl fatty acid amides, increased peroxidase activity, and peroxygenase activity such as concerted epoxidation. We investigate the mechanism of earlier reports of acyl transfer activity, the role of cyt c, and how H

Indexed as

Acyl Coenzyme ACytochromes cAnimalsCardiolipinsHydrogen PeroxideMixed Function OxygenasesOxidation-ReductionAcyl Coenzyme ACardiolipinsCytochromes cHydrogen PeroxideMixed Function OxygenasesperoxygenaseApoptosisCardiolipinFerroptosisFerryl intermediatesHeme proteinsN-acylamides

Identifiers

PMID41192137

DOI10.1016/j.jinorgbio.2025.113115

PMCPMC12742666

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.