Evidence map›Paper›PMID 41191966›Full record

ArticleThe Australian & New Zealand journal of obstetrics & gynaecology2026

Trends in the Use and Indications for Intracytoplasmic Sperm Injection Between 2005 and 2017: A State-Wide Descriptive Cohort Analysis.

Aleah Kink, Parinaz Mehdipour, Richard J Hiscock, Beverley J Vollenhoven, Catharyn J Stern, Susan P Walker, Mark P Green, Tiki Osianlis, Franca Agresta, David Wilkinson and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Australian & New Zealand journal of obstetrics & gynaecology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Aleah KinkMelbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-6034-2833
Parinaz MehdipourMelbourne Medical School, The University of Melbourne, Parkville, Victoria, Australia.
Richard J HiscockDepartment of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Parkville, Victoria, Australia.
Beverley J VollenhovenDepartment of Obstetrics and Gynaecology, Monash University, Clayton, Victoria, Australia.ORCID 0000-0002-8756-3994
Catharyn J SternReproductive Services Unit, The Royal Women's Hospital, Parkville, Victoria, Australia.
Susan P WalkerDepartment of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Parkville, Victoria, Australia.
Mark P GreenMonash IVF, Clayton, Victoria, Australia.
Tiki OsianlisNewlife IVF, East Melbourne, Victoria, Australia.
Franca AgrestaMelbourne IVF, East Melbourne, Victoria, Australia.
David WilkinsonCity Fertility Centre, Melbourne, Victoria, Australia.
Stephen TongDepartment of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Parkville, Victoria, Australia.
Roxanne HastieDepartment of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-4342-1943
Amber L KennedyDepartment of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Parkville, Victoria, Australia.
Anthea C LindquistDepartment of Obstetrics, Gynaecology and Newborn Health, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-8662-5188

Funding

FerringMercy FoundationNational Health and Medical Research Council
6 · The paper itself

Abstract

backgroundIntracytoplasmic sperm injection (ICSI) was first developed to overcome male factor infertility. ICSI has increased in uptake globally, including in cases where its use is non-essential for fertilisation.

aimsTo identify temporal trends in the use of, and indications for ICSI in an Australian context. MATERIALS AND

methodsA statewide descriptive cohort study examining the trends in ICSI uptake and reported indication/s for ICSI use. The cohort included women undergoing IVF between 2005 and 2017 at IVF clinics across Victoria, Australia that resulted in a birth after 20 weeks' gestation.

resultsThe dataset comprised 32 102 assisted reproduction cycles: 22 873 (71.3%) ICSI and 9229 (28.7%) conventional IVF. In 2005, ICSI accounted for 60.6% (1182/1952) of cycles, increasing to 79.5% (2344/2947) by 2017 (p

conclusionsDuring our study period, the total use of ICSI increased by 18.9%. Notably, most of these cycles were not medically indicated.

Indexed as

Infertility, MaleSperm Injections, IntracytoplasmicAdultCohort StudiesFemaleFertilization in VitroHumansMalePregnancySperm RetrievalVictoriafertilisation in vitrofertilityinfertilityreproductive techniques (assisted)sperm injections (intracytoplasmic)

Identifiers

PMID41191966
PMCPMC12881710

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.