Evidence map›Paper›PMID 41191934›Full record

ArticleChemistry & biodiversity2026

A Simple and Rapid New Method for Thiolated DNA Modification of Copper Sulfide Nanoparticles: Preparation of Materials for Cancer Photothermal Therapy.

Huan Du, Fang Wang, Ruyan Zhang, Yan Ma, Tianxin Weng, Gan Ning, Xiufeng Wang, Ting Zhou, Guodong Zhang, Zhiqing Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Huan DuCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Fang WangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Ruyan ZhangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Yan MaCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Tianxin WengCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Gan NingCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Xiufeng WangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Ting ZhouCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Guodong ZhangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.
Zhiqing ZhangCollege of Chemistry and Chemical Engineering, China University of Petroleum (East China), Qingdao, China.ORCID https://orcid.org/0000-0002-6854-8430

Funding

CSRD VA I01 CX003005
6 · The paper itself

Abstract

We have demonstrated a rapid and efficient strategy for modifying copper sulfide nanoparticles (CuS NPs) with thiol-modified DNA (SH-DNA) under acidic conditions (CDLp) for the first time. The CDLp method involves mixing CuS NPs with an acidic-citrate buffer (pH = 3.0), rapidly adding SH-DNA, and incubating at 25°C for 10 min to obtain the CuS-DNA conjugate. In contrast, the traditional Salt-aging method requires 12 h to produce CuS-DNA. The experimental results show that the CuS-DNA obtained by the CDLp has similar stability and photothermal properties compared with the CuS-DNA synthesized by the Salt aging method, but it shortens the modification time by more than 10 h. This saves time and costs for the subsequent preparation of photothermal therapy platforms based on CuS.

Indexed as

Antineoplastic AgentsCopperDNAMetal NanoparticlesNanoparticlesPhotothermal TherapySulfhydryl CompoundsSulfidesCell SurvivalHumansNeoplasmsAntineoplastic AgentsCoppercupric sulfideDNASulfhydryl CompoundsSulfidesbiomedical applicationscancer treatmentcopper sulfide nanoparticlesphotothermal performancesurface DNA modification

Identifiers

PMID41191934
PMCPMC13421856

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.