Evidence map›Paper›PMID 41191929›Full record

ArticleChemistry & biodiversity2026

Phytochemical and Computational Discovery of Potent Xanthine Oxidase Inhibitors From Ziziphus lotus L. Leaves and Seeds.

Fatna Bellahcene, Khedidja Benarous, Ebru Erol, Talia Serseg, Gülaçtı Topçu, Abderahmane Linani, Hicham Bouakkaz, Alaeddine Kaouka, Mohamed Yousfi

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Fatna BellahceneFundamental Sciences Laboratory, Faculty of Sciences, Amar Telidji University, Laghouat, Algeria.ORCID https://orcid.org/0009-0000-4554-2928
Khedidja BenarousFundamental Sciences Laboratory, Faculty of Sciences, Amar Telidji University, Laghouat, Algeria.ORCID https://orcid.org/0000-0001-9112-6730
Ebru ErolDepartment of Analytical Chemistry, Faculty of Pharmacy, Bezmialem Vakif University, İstanbul, Türkiye.ORCID https://orcid.org/0000-0001-6342-4298
Talia SersegFundamental Sciences Laboratory, Faculty of Sciences, Amar Telidji University, Laghouat, Algeria.ORCID https://orcid.org/0000-0001-5197-1024
Gülaçtı TopçuDepartment of Pharmacognosy, Faculty of Pharmacy, Bezmiâlem Vakıf University, İstanbul, Türkiye.ORCID https://orcid.org/0000-0002-7946-6545
Abderahmane LinaniLaboratory of Applied Sciences and Didactic, Higher Normal School of Laghouat, Laghouat, Algeria.ORCID https://orcid.org/0000-0002-2436-8147
Hicham BouakkazFundamental Sciences Laboratory, Faculty of Sciences, Amar Telidji University, Laghouat, Algeria.ORCID https://orcid.org/0000-0003-2254-3578
Alaeddine KaoukaLaboratory of Applied Sciences and Didactic, Higher Normal School of Laghouat, Laghouat, Algeria.ORCID https://orcid.org/0000-0002-1118-7603
Mohamed YousfiFundamental Sciences Laboratory, Faculty of Sciences, Amar Telidji University, Laghouat, Algeria.ORCID https://orcid.org/0000-0003-3947-9867

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ziziphus lotus (L.), traditionally recognised for its anti-inflammatory and antioxidant properties, has received limited scientific exploration regarding its potential as an antigout agent. This study provides the first investigation of the inhibitory capacity of Z. lotus seed and leaf extracts against bovine xanthine oxidase (BXO), a key enzyme in uric acid biosynthesis and the pathogenesis of gout. To characterise its bioactive constituents, the potent extract was subjected to liquid chromatography-high-resolution electrospray ionisation mass spectrometry (LC-HRESIMS)-based phytochemical profiling. In vitro evaluation confirmed potent inhibitory effects, with the seed extract (IC

Indexed as

Drug DiscoveryEnzyme InhibitorsPhytochemicalsPlant ExtractsSeedsXanthine OxidaseZiziphusAnimalsCattleDose-Response Relationship, DrugMolecular Docking SimulationMolecular StructurePlant LeavesStructure-Activity RelationshipEnzyme InhibitorsPhytochemicalsPlant ExtractsXanthine OxidaseADMETinhibitoryliquid chromatography–high‐resolution electrospray ionisation mass spectrometry (LC–HRESIMS)xanthine oxidaseZiziphus lotus

Identifiers

PMID41191929
PMCPMC13421949

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.