Trial reportThe oncologist2025
Narrative therapy and resilience training improve recovery and survival after intersphincteric resection for low rectal cancer: a randomized trial.
Trial report in The oncologist, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Psychological Resilience in Surgery: Psychobiological Pathways, Clinical Impact, and Perioperative Modulation-A Narrative Review.Journal of personalized medicine · 2026Review
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients undergoing intersphincteric resection (ISR) for low rectal cancer often experience persistent bowel dysfunction, psychological distress, and compromised quality of life, especially in the context of preventive stoma creation. These challenges can negatively affect recovery, immune function, and long-term prognosis. Psychosocial interventions, such as narrative therapy and resilience training, may mitigate these effects, yet their integrated application in ISR populations remains unexplored.
methodsIn this single-center randomized controlled trial, 178 patients with stage I-III low rectal cancer who underwent ISR between October 2019 and October 2021 at the First Affiliated Hospital of Soochow University were randomized to receive either standard care or a structured 6-month intervention combining narrative therapy and resilience training. Primary outcomes included psychological resilience (CD-RISC), emotional well-being (HADS), sleep quality (PSQI), and nutritional recovery (serum albumin, prealbumin, BMI). Secondary endpoints encompassed postoperative complications, systemic inflammation (CRP, IL-6, TNF-α), and 2-year disease-free survival (DFS) and overall survival (OS). All analyses followed the intention-to-treat principle.
resultsThe intervention group demonstrated significantly greater improvements in psychological and nutritional parameters (all P < .01), fewer complications (12.4% vs. 23.6%, P = .035), and reduced inflammatory markers on postoperative day 7. At 24 months, both DFS (89.2% vs. 75.3%, P = .028) and OS (93.1% vs. 81.6%, P = .031) were significantly higher in the intervention group. Effect sizes (Cohen's d) and minimal clinically important differences (MCIDs) were assessed to support the interpretation of clinical relevance.
conclusionAn integrated psychosocial intervention significantly enhanced functional recovery and long-term oncologic outcomes following ISR. These findings underscore the value of incorporating structured psychological support into postoperative care for low rectal cancer.
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