Evidence map›Paper›PMID 41191856›Full record

ArticleNeurology2025

Effects of Heavy Alcohol Use on Acute Intracerebral Hemorrhage and Cerebral Small Vessel Disease.

Mette Foldager Hindsholm, Alvin S Das, Elif Gokcal, Andrea Morotti, Ofer Rotschild, Claus Ziegler Simonsen, Zora Dipucchio, Anand Viswanathan, Steven M Greenberg, Christopher D Anderson and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Mette Foldager HindsholmDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.ORCID 0009-0003-9482-2792
Alvin S DasDepartment of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA.ORCID 0000-0003-2313-977X
Elif GokcalDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.
Andrea MorottiDepartment of Clinical and Experimental Sciences, Neurology Unit, University of Brescia, Italy.ORCID 0000-0002-6558-1155
Ofer RotschildDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.
Claus Ziegler SimonsenDepartment of Neurology, Aarhus University Hospital, Department of Clinical Medicine, Aarhus University, Denmark; and.ORCID 0000-0003-1363-0266
Zora DipucchioDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.
Anand ViswanathanDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.ORCID 0000-0001-5398-1816
Steven M GreenbergDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.ORCID 0000-0003-1792-8887
Christopher D AndersonDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.ORCID 0000-0002-0053-2002
Jonathan RosandDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.ORCID 0000-0002-1014-9138
Joshua N GoldsteinDepartment of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston.ORCID 0000-0002-6406-1828
M Edip GurolDepartment of Neurology, Massachusetts General Brigham, Harvard Medical School, Boston.

Funding

Molecular and Physiological Mechanisms of Hypertensive Cerebral MicroangiopathyR01NS114526 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2020 to 2024
$4.4M
Molecular Neuroimaging of Disease Mechanisms in Cerebral Amyloid AngiopathyK23NS083711 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI GUROL, MAHMUT EDIP · 2014 to 2018
$988k
NINDS NIH HHS K23 NS083711NINDS NIH HHS R01 NS114526
6 · The paper itself

Abstract

BACKGROUND AND

objectivesHeavy alcohol use (HAU) is a modifiable risk factor that may influence intracerebral hemorrhage (ICH) severity and cerebral small vessel disease (cSVD), but its role remains insufficiently understood. We aimed to investigate how HAU is associated with acute ICH characteristics and cSVD burden.

methodsIn this cross-sectional study, we analyzed prospectively collected data from consecutive patients admitted with spontaneous, nontraumatic ICH to Massachusetts General Hospital between 2003 and 2019. HAU was defined as regular alcohol consumption of ≥3 drinks per day. Multivariable regression models assessed associations between HAU and acute ICH clinical and radiologic features and MRI markers of cSVD.

resultsAmong 1,600 patients (851 male patients [53%]; median age 75 [interquartile range 64-82] years), 104 (7%) met criteria for HAU. Compared with the non-HAU cohort, patients with HAU were significantly younger at ICH onset (median 64 vs 75 years; DISCUSSION: HAU is associated with younger age at ICH onset, larger hematoma size, and imaging features consistent with more advanced hypertensive cSVD, including a greater burden of white matter hyperintensities. These findings suggest that HAU may exacerbate acute ICH severity and accelerate long-term cerebral small vessel pathology. Study limitations include the cross-sectional design, MRI availability restricted to a subset, and lack of detailed lifetime alcohol exposure. Future studies should clarify alcohol-related mechanisms underlying cSVD progression and ICH severity and inform prevention strategies.

Indexed as

Alcohol DrinkingAlcoholismCerebral HemorrhageCerebral Small Vessel DiseasesAgedAged, 80 and overCross-Sectional StudiesFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedProspective StudiesRisk Factors

Identifiers

PMID41191856
PMCPMC13617770

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.