ArticleJournal of the American Chemical Society2025
Visualizing the Invisible: Dual Click Imaging of Ruthenium-Based Photoactivated Chemotherapy Agents and Their DNA Synthesis Inhibition in Fixed Cancer Cells.
Anja Busemann, Lisa Rieger, Rachael M Cunningham, Sam C Davidse, Irene Regeni, Ingrid Flaspohler, Claudia Schmidt, Xue-Quan Zhou, Vincent van Rixel, Maxime A Siegler and 5 more
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
15 authors.
Anja BusemannLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Lisa RiegerInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.
Rachael M CunninghamDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.
Sam C DavidseLeiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Irene RegeniLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.ORCID 0000-0001-9102-3053
Ingrid FlaspohlerLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Claudia SchmidtInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany.ORCID 0000-0001-8532-2604
Xue-Quan ZhouLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Vincent van RixelLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.
Maxime A SieglerSmall Molecule X-Ray Facility, Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, United States.ORCID 0000-0003-4165-7810
Ingo OttInstitute of Medicinal and Pharmaceutical Chemistry, Technische Universität Braunschweig, Beethovenstrasse 55, 38106 Braunschweig, Germany.ORCID 0000-0002-8087-4618
Sylvia E Le DévédecLeiden Academic Centre for Drug Research (LACDR), Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.ORCID 0000-0002-0615-9616
Hans-Achim WagenknechtInstitute of Organic Chemistry, Karlsruhe Institute of Technology (KIT), Fritz-Haber-Weg 6, 76131 Karlsruhe, Germany.ORCID 0000-0003-4849-2887
Victoria J DeRoseDepartment of Chemistry and Biochemistry, University of Oregon, Eugene, Oregon 97403, United States.ORCID 0000-0001-5761-671X
Sylvestre BonnetLeiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, Netherlands.ORCID 0000-0002-5810-3657
Funding
No grant is acknowledged in the PubMed record.
6 · The paper itself
Abstract
Like many drugs, ruthenium-based photoactivated chemotherapy (PACT) complexes are hard to follow in cells due to their absence of emissive properties. Here, two alkyne-functionalized Ru-based PACT compounds with the formula [Ru(HCC-tpy)(N̂N)(Hmte)](PF
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Visualizing the Invisible: Dual Click Imaging of Ruthenium-Based Photoactivated Chemotherapy Agents and Their DNA Synthesis Inhibition in Fixed Cancer Cells. · full record | OpenQuestion